P53
- Product Name
- P53
- Chemical Name
- P53
- Synonyms
- P53;TP53;LFS1;BCC7;TRP53;NM23A;BMFS5;FLJ92943;Cys51Stop;HGNC:11998
- CBNumber
- CB3193684
- Molecular Formula
- C36H80O10P4Tc+
- Formula Weight
- 895.82
- MOL File
- Mol file
P53 Property
- storage temp.
- -20°C
- form
- buffered aqueous solution
- color
- clear colorless
- biological source
- rabbit
Safety
- WGK Germany
- WGK 1
- HS Code
- 3504009000
- Storage Class
- 12 - Non Combustible Liquids
N-Bromosuccinimide Price
- Product number
- SRP2108
- Product name
- p53 (1-81), mutant, GST tagged human
- Purity
- recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
- Packaging
- 10μG
- Price
- $271
- Updated
- 2025/07/31
- Product number
- SRP2107
- Product name
- p53 (1-81), wild type, GST tagged human
- Purity
- recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
- Packaging
- 10μG
- Price
- $286
- Updated
- 2025/07/31
- Product number
- SRP2078
- Product name
- p53 (1-342) C-terminal deletion human
- Purity
- recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
- Packaging
- 5μG
- Price
- $442
- Updated
- 2025/07/31
- Product number
- SRP2077
- Product name
- p53 (1-363) C-terminal deletion human
- Purity
- recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
- Packaging
- 5μG
- Price
- $549
- Updated
- 2025/07/31
- Product number
- SAB5701830
- Product name
- Anti-Phospho-p53-S376 antibody produced in rabbit
- Packaging
- 100μL
- Price
- $418
- Updated
- 2025/07/31
P53 Chemical Properties,Usage,Production
Uses
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Biological Activity
Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.', 'p53 was identified as a tumor suppressor by showing th at this protein has the ability to block transformation and to inhibit tumor cell growth. In addition, p53 is a transcription factor capable of regulating the expression of a subset of downstream genes. Mutation of two specific N-terminal residues in p53 (residues Leu22 and Trp23) impairs the ability of p53 to transactivate and has been correlated with its ability to bind TAFII40 and TAFII60 (or TAFII31 and TAFII70) suggesting th at one or both of these interactions is important for activation. Mutation of residues 22 and 23 to Ala does not affect binding to TBP, although mutation of these residues to charged amino acids has been reported to disrupt the p53-TBP interaction. Different mutations in p53 gene have been characterized in a variety of human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis.
P53 Preparation Products And Raw materials
Raw materials
Preparation Products
P53 Suppliers
- Tel
- 021-61415566 800-8193336
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- Country
- China
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- 02-400-810-9781 400810978
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- 420-549124185
- info@biovendor.com
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- China
- ProdList
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