2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Product Name: 2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
CAS No.: 5094-12-2
Chemical Name: 2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Synonyms: 0/2/94;2-methyl-2,3,4,5-tetrahydro-1h-pyridine;2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole;3-Methyl-1,2,3,4-tetrahydro-.gamma.-carboline;2-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indole;2,3,4,5-Tetrahydro-2-methyl-1H-pyrido[4,3-b]indole;1,2,3,4-Tetrahydro-2-methyl-5H-pyrido[4,3-b]indole;2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;1H-pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2-methyl-;1H-Pyrido(4,3-b)indole, 2,3,4,5-tetrahydro-2-methyl-
CBNumber: CB32070693
Molecular Formula: C12H14N2
Formula Weight: 186.25
MOL File: 5094-12-2.mol

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2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole Property

Melting point:: 170.0 to 174.0 °C
Boiling point:: 326.4±32.0 °C(Predicted)
Density: 1.165±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 17.42±0.20(Predicted)
color: White to Orange to Green
λmax: 291nm(MeOH)(lit.)

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Safety

RTECS: UV0830000
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2717
Product name: 2-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $142
Updated: 2025/07/31

TCI Chemical

Product number: M2717
Product name: 2-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $429
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: CHM0303776
Product name: 2,3,4,5-TETRAHYDRO-2-METHYL-1H-PYRIDO[4,3-B]INDOLE
Purity: 95.00%
Packaging: 5MG
Price: $499.74
Updated: 2021/12/16

Chem-Impex

Product number: 43008
Product name: 2-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-β]indole,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $514.22
Updated: 2021/12/16

Matrix Scientific

Product number: 038811
Product name: 2-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Packaging: 500mg
Price: $120
Updated: 2021/12/16

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2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole Chemical Properties,Usage,Production

Synthesis Reference(s)

Synthesis, p. 327, 1971 DOI: 10.1055/s-1971-21736

Synthesis

1445-73-4

100-63-0

5094-12-2

Synthesis of 2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (17): phenylhydrazine (1.0 g, 9.3 mmol) and N-methyl-4-piperidone (1.1 g, 9.3 mmol) were dissolved in 1,4-dioxane (35 mL) and the mixture was cooled down to 0 °C. Concentrated sulfuric acid (5 mL) was slowly added dropwise at 0 °C and under stirring conditions, and a precipitate was generated during the reaction. Subsequently, the reaction mixture was heated to 60 °C and maintained for 1 hour until the precipitate was completely dissolved. The reaction mixture was continued to be stirred at 60°C for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to about 12 by addition of saturated aqueous sodium bicarbonate, assisted by addition of a small amount of solid sodium hydroxide if necessary. The organic product was extracted with chloroform (3 x 20 mL), the organic phases were combined and washed with brine (15 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by column chromatography (elution gradient: hexane solution of 0-80% ethyl acetate) afforded the target product (1.6 g, 93% yield) as a beige solid.1H NMR (400 MHz, DMSO-d6): δ 10.80 (s, 1H), 7.30 (m, 2H), 6.98 (m, 2H), 3.53 (s, 2H), 2.79 (t, J = 5.2 Hz, 2H), 2.71 (t, J = 5.4 Hz, 2H), 2.43 (s, 3H).13C NMR APT (100 MHz, CDCl3): δ 136.2 (CH), 132.0 (CH), 126.0 (CH), 121.0 (CH2), 119.1 (CH2), 117.4 (CH2), 110.7 (CH2), 117.4 (CH2), 117.4 (CH2), 117.4 (CH2), 117.4 (CH2), 117.4 (CH2), 117.4 (CH2) 110.7 (CH2), 108.3 (CH), 52.5 (CH2), 51.8 (CH2), 45.8 (CH3), 23.5 (CH2) ESI-HRMS (m/z): [M + H]+ Calculated value C12H14N2, 187.1230; measured value, 187.1228.

References

[1] Journal of the American Chemical Society, 2010, vol. 132, # 31, p. 10842 - 10846
[2] Patent: WO2011/11186, 2011, A2. Location in patent: Page/Page column 51
[3] Organic Letters, 2018, vol. 20, # 6, p. 1589 - 1592
[4] Tetrahedron Letters, 2004, vol. 45, # 24, p. 4781 - 4783
[5] Patent: WO2013/78544, 2013, A1. Location in patent: Paragraph 00109-00110

2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole Suppliers

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