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GALLIUM NITRATE

Product Name
GALLIUM NITRATE
CAS No.
13494-90-1
Chemical Name
GALLIUM NITRATE
Synonyms
ganite;nsc-15200;Ga(NO3)3nH2O;Ga(NO3)3?5H2O;Wln: ga N-o3*3;GALLIUM NITRATE;galliumtrinitrate;Gallium(Ⅲ) nitrate;GALLIUM (III) NITRATE;Nitricacid,galliumsalt
CBNumber
CB3209552
Molecular Formula
GaH4NO3
Formula Weight
135.76
MOL File
13494-90-1.mol
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GALLIUM NITRATE Property

Melting point:
110°C (dec.)
solubility 
soluble in H2O, ethanol, ethyl ether
form 
Liquid
color 
white crystals, crystalline powder
Water Solubility 
It is soluble in water.
Exposure limits
ACGIH: TWA 2 ppm; STEL 4 ppm
OSHA: TWA 2 ppm(5 mg/m3)
NIOSH: IDLH 25 ppm; TWA 2 ppm(5 mg/m3); STEL 4 ppm(10 mg/m3)
EPA Substance Registry System
Gallium nitrate (13494-90-1)
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Safety

Risk Statements 
8-36/37/38
Safety Statements 
17-26-36/37/39
RIDADR 
1477
TSCA 
Yes
HazardClass 
5.1
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H272May intensify fire; oxidizer

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P221Take any precaution to avoid mixing with combustibles/…

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS001582
Product name
Gallium (III) nitrate, solution Ga 9-10% W/W
Purity
AldrichCPR
Packaging
1G
Price
$70.9
Updated
2024/03/01
Alfa Aesar
Product number
043484
Product name
Gallium(III) nitrate solution, Ga 9-10% w/w
Packaging
50g
Price
$127
Updated
2024/03/01
Alfa Aesar
Product number
043484
Product name
Gallium(III) nitrate solution, Ga 9-10% w/w
Packaging
250g
Price
$434.65
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0005631
Product name
GALLIUM NITRATE
Purity
95.00%
Packaging
5MG
Price
$497.08
Updated
2021/12/16
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GALLIUM NITRATE Chemical Properties,Usage,Production

Description

Gallium nitrate, initially developed as an anticancer agent, was introduced by Fujisawa as an orphan drug for the treatment of cancer-related hypercalcemia and bone metastases that do not respond to adequate hydration. The compound acts specifically on bone by inhibiting calcium resorption and also possibly by stimulating bone formation. Compared with calcitonin and etidronate, gallium nitrate is more potent and substantially longer acting. Other potential uses could be in the treatment of osteoporosis and Paget’s disease.

Chemical Properties

The structural formula of gallium nitrate is Ga(NO3)3. Gallium nitrate is an anhydrate salt that is very soluble in water and soluble in 95% ethanol. It is stable in commonly used intravenous fluids for 14 days at room temperature and at 5 ℃, and physically compatible for injection with selected drug products, with the exception of diazepam injection.This chemical is an oxidizer, and is probably combustible

Chemical Properties

white; crystal(s) powder(s) [MER06]

Originator

Memorial Sloan-Kettering Cancer Center (U.S.A.)

Uses

Gallium is the second metal ion with clinical activity used in cancer treatment. Gallium nitrate has demonstrated antitumor activity in a variety of murine tumor models, including Walker 256 carcinosarcoma, fibrosarcoma M-89, leukemia K-1964, adenocarcinoma 755, mammary carcinoma YMC, reticulum cell sarcoma A-RCS, lymphoma P1798, and osteosarcoma 124F. It was, however, ineffective in ascites, leukemias, plasma cell tumors, or Ehrlich carcinoma. In phase II evaluation studies, gallium nitrate has shown antitumor activity in patients with either refractory lymphomas or small-cell lung carcinomas or bladder cancer, with total objective response rates of 28% and 11%, respectively. This drug has displayed its strongest antineoplastic activity in the treatment of non-Hodgkin’s lymphoma and bladder cancer.
In addition, according to two phase III comparative trials,thanks to an inhibitory effect on calcium reabsorption from bone, gallium nitrate is superior to alternative therapies in the treatment of hypercalcemia associated with malignancy and related disease states. Based on its clinical efficacy, gallium nitrate (Ganite ) was approved by the Food and Drug Administration (FDA) for the treatment of cancerassociated hypercalcemia.
Apart from its ability to control hypercalcemia, gallium nitrate has been shown to inhibit bone turnover and decrease osteolysis in patients with multiple myeloma and in patients with bone metastases from a variety of different cancers.

Uses

Gallium(III) nitrate solution, is used as the material for producing gallium salts and for scientific research and chemical reagent. It is also used as an intermediate.

Uses

Regulator (calcium).

brand name

Ganite (Genta).

General Description

White crystals.

Air & Water Reactions

Deliquescent. Water soluble.

Reactivity Profile

Oxidizing agents, such as GALLIUM NITRATE, can react with reducing agents to generate heat and products that may be gaseous (causing pressurization of closed containers). The products may themselves be capable of further reactions (such as combustion in the air). The chemical reduction of materials in this group can be rapid or even explosive, but often requires initiation (heat, spark, catalyst, addition of a solvent). Explosive mixtures of inorganic oxidizing agents with reducing agents often persist unchanged for long periods if initiation is prevented. Such systems are typically mixtures of solids, but may involve any combination of physical states. Some inorganic oxidizing agents are salts of metals that are soluble in water; dissolution dilutes but does not nullify the oxidizing power of such materials. Organic compounds, in general, have some reducing power and can in principle react with compounds in this class. Actual reactivity varies greatly with the identity of the organic compound. Inorganic oxidizing agents can react violently with active metals, cyanides, esters, and thiocyanates.

Fire Hazard

Flash point data for GALLIUM NITRATE are not available, but GALLIUM NITRATE is probably combustible.

Pharmaceutical Applications

In clinical trials, gallium nitrate has proved to be highly active as an antitumour agent especially against non-Hodgkin’s lymphoma and bladder cancer. The cytotoxic activity of gallium nitrate has been demonstrated as single agent and as part of combination therapy, for example, together with fluorouracil. Gallium nitrate shows a relatively low toxicity and does not produce myelosuppression, which is a significant advantage over other traditional anticancer agents. Furthermore, it does not appear to show any cross-resistance with conventional chemotherapeutic agents.
These studies have also shown that gallium nitrate is able to decrease serum calcium levels in patients with tumour-induced hypercalcaemia. Subsequently, several studies have been carried out comparing traditional bisphosphonate drugs with gallium nitrate in their ability to decrease the calcium levels that are elevated as a result of cancer. Based on the clinical efficacy, gallium nitrate injections (GaniteTM) was granted approval by the FDA for the treatment of cancer-associated hypercalcaemia. Gallium nitrate is also believed to inhibit the bone turnover and therefore to decrease osteolysis, the active reabsorption of bone material, in patients with bone metastasis secondary to other cancers.

Carcinogenicity

Studies on the antitumor activity of gallium nitrate have shown that it is particularly active against solid tumors. It has demonstrated antitumor activity in a variety of murine tumor models, including Walker carcinosarcoma 256, fibrosarcoma M-89, leukemia K-1964, adenocarcinoma 755, mammary carcinoma YMC, reticulum cell sarcoma A-RCS, lymphoma P1798, and osteosarcoma 124F.

GALLIUM NITRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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GALLIUM NITRATE Suppliers

Meryer (Shanghai) Chemical Technology Co., Ltd.
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View Lastest Price from GALLIUM NITRATE manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
GALLIUM NITRATE 13494-90-1
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-08
hebei yanxi chemical co., LTD
Product
GALLIUM NITRATE 13494-90-1
Price
US $100.00-20.00/kgkg
Min. Order
1kgkg
Purity
0.99
Supply Ability
10000
Release date
2023-10-25
Career Henan Chemical Co
Product
GALLIUM NITRATE 13494-90-1
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

13494-90-1, GALLIUM NITRATERelated Search:


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