1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID
- Product Name
- 1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID
- CAS No.
- 118133-15-6
- Chemical Name
- 1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID
- Synonyms
- N-(Ethoxycarbonyl)isonipecoticacid;1-(Ethoxycarbonyl)isonipecotic Acid;1-carbethoxyPiperidine-4-carboxylic acid;N-(Ethoxycarbonyl)piperidine-4-carboxylicacid;1,4-Piperidinedicarboxylic Acid 1-Ethyl Ester;1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID;1-(ETHOXYCARBONYL)PIPERIDINE-4-CARBOXYLIC ACID;4-Carboxy-1-(ethoxycarbonyl)piperidine, Ethyl 4-carboxypiperidine-1-carboxylate
- CBNumber
- CB3212819
- Molecular Formula
- C9H15NO4
- Formula Weight
- 201.22
- MOL File
- Mol file
1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID Property
- Melting point:
- 68-70
- Boiling point:
- 343.0±35.0 °C(Predicted)
- Density
- 1.227
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.56±0.20(Predicted)
- color
- White to Light yellow
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E1208
- Product name
- 1-(Ethoxycarbonyl)-4-piperidinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- E1208
- Product name
- 1-(Ethoxycarbonyl)-4-piperidinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $105
- Updated
- 2025/07/31
- Product number
- P481885
- Product name
- 1,4-PiperidinedicarboxylicAcid1-EthylEster
- Packaging
- 10g
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- 046160
- Product name
- 1-(Ethoxycarbonyl)-4-piperidinecarboxylic acid
- Purity
- >95%
- Packaging
- 500mg
- Price
- $14
- Updated
- 2021/12/16
- Product number
- OR14113
- Product name
- 1-(Ethoxycarbonyl)piperidine-4-carboxylic acid
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
1,4-Piperidinedicarboxylic Acid 1-Ethyl Ester, is an starting material in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.
Synthesis
498-94-2
541-41-3
118133-15-6
Example 1- Preparation of 1-(ethoxycarbonyl)piperidine-4-carboxylic acid Sodium hydroxide (154.8 g) was dissolved in pure water (750 ml) at 0-10°C and isopiperidine carboxylic acid (250 g) was added. Subsequently, ethyl chloroformate (231 ml) was added slowly and dropwise at 5-20°C. The reaction mixture was warmed up to 20-30°C and maintained at this temperature for 3 hours. Upon completion of the reaction, the reaction solution was acidified with hydrochloric acid to pH 1-2. Toluene (750 ml) was added to the reaction solution and stirred at 25-30 °C for 15 min. The organic layer was separated and concentrated under reduced pressure at below 70 °C to give a residue. The residue was mixed with cyclohexane (1250 ml), heated to 60-70 °C then cooled to 25-30 °C and kept for 1 hour. The resulting solid was filtered, washed with cyclohexane (1250 ml) and dried at 50-55 °C. Yield: 92%.
References
[1] Patent: WO2014/83571, 2014, A1. Location in patent: Page/Page column 17
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 11, p. 4680 - 4692
[3] Patent: US5663200, 1997, A
[4] Archiv der Pharmazie, 2016, p. 614 - 626
1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-20221225 13917446399
- Fax
- QQ:115820162
- zwchem@163.com
- Country
- China
- ProdList
- 616
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 0519-85607258 13912342323;
- Fax
- 0519-85607278
- sales@joyouschem.com
- Country
- China
- ProdList
- 294
- Advantage
- 60
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID manufacturers
- Product
- 1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID 118133-15-6
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2018-07-27