ChemicalBook > CAS DataBase List > JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride

JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride

Product Name
JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
CAS No.
37936-89-3
Chemical Name
JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
Synonyms
JP 92;NSC 43036;(+)-Norfenfluramine;)-Norfenfluramine hydrochloride;(+)-NORFENFLURAMINE HYDROCHLORIDE;(2S)-1-[3-(trifluoromethyl)phenyl]propan-2-amine;(S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine HCl;(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE HYDROCHLORIDE;(S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine hydrochloride;S-(+)-alpha-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
CBNumber
CB32130867
Molecular Formula
C10H12F3N.ClH
Formula Weight
239.667
MOL File
37936-89-3.mol
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JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride Property

storage temp. 
2-8°C
solubility 
H2O: >10mg/mL
form 
powder
color 
white
Water Solubility 
H2O: >10mg/mL
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N3288
Product name
(+)-Norfenfluramine hydrochloride
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$173
Updated
2025/07/31
Sigma-Aldrich
Product number
N3288
Product name
(+)-Norfenfluramine hydrochloride
Purity
≥98% (HPLC), powder
Packaging
50mg
Price
$783
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
MTB0002477
Product name
(+)-NORFENFLURAMINE HYDROCHLORIDE
Purity
95.00%
Packaging
50MG
Price
$1164.24
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
MTB0002477
Product name
(+)-NORFENFLURAMINE HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$730.68
Updated
2021/12/16
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JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride Chemical Properties,Usage,Production

Uses

(S)-Norfenfluramine Hydrochloride is a metabolite of (S)-(+)-Fenfluramine Hydrochloride (F247596); an anorexic.

Biochem/physiol Actions

(+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is primarily responsible for the anorexic effect, as well as side effects; (+)-norfenfluramine causes vasoconstriction and a blood pressure increase in rats with normal blood; acts primarily on the cytoplasmic pool of serotonin; more potent than fenfluramine at inducing dopamine release.

in vivo

(+)-Norfenfluramine (1-300 μg/kg, i.v.) hydrochloride induces pressor response in conscious SHAM and DOCA-salt rats[1].
(+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) hydrochloride decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats[3].

Animal Model:Conscious SHAM and DOCA-salt rats[1].
Dosage:1-300 μg/kg
Administration:Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals.
Result:Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19).

IC 50

5-HT2B Receptor: 11.2 nM (Ki); 5-HT2C Receptor: 324 nM (Ki); 5-HT2A Receptor: 1516 nM (Ki)

JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride Suppliers

China 23 India 2 United Kingdom 1 United States 2 Global 28
Sigma-Aldrich
Tel
021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
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Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
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15393
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Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd
Tel
037188900765 18037465274
Fax
QQ3430974218
Email
enyawanglei@sina.cn
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China
ProdList
14000
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Shanghai Kaiwei Chemical Technology Co., Ltd.
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021-58461859 15821823057
Email
service@aiviche.com
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China
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49312
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Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
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China
ProdList
24731
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Energy Chemical
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021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
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China
ProdList
44918
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Wuhan Topule
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+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
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China
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7988
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Perseverant (Tianjin) Biomedical Technology Co., Ltd
Tel
17777863707
Email
17777863707@189.cn
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China
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340
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37936-89-3, JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochlorideRelated Search:


  • JP 92, NSC 43036, S-(+)-α-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
  • JP 92
  • NSC 43036
  • (S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE HYDROCHLORIDE
  • (S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine hydrochloride
  • JP 92, NSC 43036, S-(+)-alpha-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
  • S-(+)-alpha-Methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
  • (S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine HCl
  • (+)-Norfenfluramine
  • (+)-NORFENFLURAMINE HYDROCHLORIDE
  • )-Norfenfluramine hydrochloride
  • (2S)-1-[3-(trifluoromethyl)phenyl]propan-2-amine
  • 37936-89-3