ChemicalBook > CAS DataBase List > METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE

METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE

Product Name: METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE
CAS No.: 67808-64-4
Chemical Name: METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE
Synonyms: Methyl 5-forMylthiophene-2-carboxylate;METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE;5-Formyl-2-thiophenecarboxylic acid methyl ester;5-FORMYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;2-Thiophenecarboxylic acid, 5-forMyl-, Methyl ester;METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE ISO 9001：2015 REACH
CBNumber: CB3214156
Molecular Formula: C7H6O3S
Formula Weight: 170.19
MOL File: 67808-64-4.mol

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METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE Property

Melting point:: 102℃
Boiling point:: 304.3±27.0 °C(Predicted)
Density: 1.324±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: Light brown to off-white Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M305723
Product name: Methyl5-Formylthiophene-2-carboxylate
Packaging: 500mg
Price: $155
Updated: 2021/12/16

Matrix Scientific

Product number: 075628
Product name: 5-Formylthiophene-2-carboxylic acid methyl ester
Purity: 95+%
Packaging: 250mg
Price: $231
Updated: 2021/12/16

AK Scientific

Product number: W7818
Product name: 2-Thiophenecarboxylicacid,5-formyl-,methylester
Packaging: 10g
Price: $419
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 37830
Product name: Methyl5-formylthiophene-2-carboxylate
Purity: 95+%
Packaging: 1g
Price: $449
Updated: 2021/12/16

Matrix Scientific

Product number: 075628
Product name: 5-Formylthiophene-2-carboxylic acid methyl ester
Purity: 95+%
Packaging: 1g
Price: $500
Updated: 2021/12/16

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METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron, 64, p. 688, 2008 DOI: 10.1016/j.tet.2007.11.030

Synthesis

4565-31-5

74-88-4

67808-64-4

Step 1. 5-formyl-2-thiophenecarboxylic acid (2.34 g, 15 mmol) was dissolved in DMF (25 ml) with sodium carbonate (5.57 g, 52.5 mmol) at 25 °C and iodomethane (1.15 ml, 18 mmol) was added slowly. The reaction mixture was stirred at room temperature for 20 h before the reaction was terminated by addition of water and saturated aqueous NH4Cl solution. The reaction mixture was filtered to collect the solid precipitate to give the crude methyl 5-formylthiophene-2-carboxylate. The filtrate was extracted with EtOAc (3 x 30 ml), the organic phases were combined and washed sequentially with water and brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by fast column chromatography and combined with the previously collected solids to give the final methyl 5-formylthiophene-2-carboxylate as a white solid (1.60 g, 62% yield).ESI-MS (m/z): 171.2 (M+H+).

References

[1] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 1, p. 17 - 28
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 12, p. 5982 - 5986
[3] Patent: WO2008/124582, 2008, A1. Location in patent: Page/Page column 130
[4] Patent: US5047554, 1991, A
[5] Patent: US2006/293343, 2006, A1. Location in patent: Page/Page column 89

METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE manufacturers

Career Henan Chemical Co

Product: METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE 67808-64-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-10

67808-64-4, METHYL 5-FORMYL-2-THIOPHENECARBOXYLATERelated Search:

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5-FORMYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE

5-Formyl-2-thiophenecarboxylic acid methyl ester

2-Thiophenecarboxylic acid, 5-forMyl-, Methyl ester

Methyl 5-forMylthiophene-2-carboxylate

METHYL 5-FORMYL-2-THIOPHENECARBOXYLATE ISO 9001：2015 REACH

67808-64-4