7-Octynoic acid
- Product Name
- 7-Octynoic acid
- CAS No.
- 10297-09-3
- Chemical Name
- 7-Octynoic acid
- Synonyms
- oct-7-ynoic acid;7-Octynoic acid;WJBHDZBQZOMDFF-UHFFFAOYSA-N
- CBNumber
- CB32153859
- Molecular Formula
- C8H12O2
- Formula Weight
- 140.18
- MOL File
- 10297-09-3.mol
7-Octynoic acid Property
- Melting point:
- 19°C
- Boiling point:
- 290.64°C (rough estimate)
- Density
- 1.0450 (rough estimate)
- refractive index
- 1.4502
- solubility
- DMSO: 150 mg/mL (1070.05 mM)
- form
- Liquid
- pka
- 4.74±0.10(Predicted)
- color
- Colorless to light pink
- Water Solubility
- Water: 5 mg/mL (35.67 mM)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B508923
- Product name
- Oct-7-ynoicAcid
- Packaging
- 100mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 2646BB
- Product name
- 7-Octynoicacid
- Packaging
- 500mg
- Price
- $988
- Updated
- 2021/12/16
- Product number
- A393928
- Product name
- Oct-7-ynoicacid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- A393928
- Product name
- Oct-7-ynoicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $137
- Updated
- 2021/12/16
- Product number
- A393928
- Product name
- Oct-7-ynoicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $333
- Updated
- 2021/12/16
7-Octynoic acid Chemical Properties,Usage,Production
Uses
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Definition
ChEBI: 7-octynoic acid is a medium-chain fatty acid.
IC 50
Alkyl-Chain
References
[1] Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. DOI:10.1016/j.ccell.2019.10.002
7-Octynoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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