Tomentosin Property

Melting point:

121-122 °C(Solv: methanol (67-56-1))

Boiling point:

416.2±45.0 °C(Predicted)

Density 

1.08±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO (50 mg/ml)

form 

oil

color 

Yellow

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.

Hazard and Precautionary Statements (GHS)

Tomentosin Chemical Properties,Usage,Production

Description

Extracts of Inula which contain tomentosin (33649-15-9) have been used for centuries in traditional medicine for the treatment of inflammation.1 It suppresses the production of inflammatory mediators in RAW264.7 cells by inhibiting NFkB activation.2 It induces telomere shortening and caspase-dependent apoptosis in cervical cancer cells3 and induces apoptosis in human osteosarcoma MG-63 cells4. It causes G2/M arrest and apoptosis in human melanoma cell lines.5

Definition

ChEBI: Tomentosin is a sesquiterpene lactone.

References

Lu et al. (2012), Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation; Ethnopharmacol. 143 151 Park et al. (2014), Suppressive effect of tomentosin on the production of inflammatory mediators in RAW264.7 cells; Biol. Pharm. Bull., 37 1177 Merghoub et al. (2017), Tomentosin Induces Telomere Shortening and Caspase-Dependent Apoptosis in Cervical Cancer Cells; J. Cell Biochem., 118 1689 Lee et al. (2019), Tomentosin Displays Anti-Carcinogenic Effect in Human Osteosarcoma MG-63 Cells via the Induction of Intracellular Reactive Oxygen Species; Int. J. Mol. Sci., 20(6) 1508 Rozenblat et al. (2008), Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines; Biochem. Pharmacol., 75 369