ChemicalBook > CAS DataBase List > N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

Product Name: N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
CAS No.: 17328-16-4
Chemical Name: N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
Synonyms: TC-E 5003;N'-(Sulfonyldi-4;TC-E 5003 (NSC-30176);TC-E 5003, 10 mM in DMSO;1-phenylene)bis(2-chloroacetamide);4',4'-SULFONYLBIS(2-CHLOROACETANILIDE);4',4'-SULFONYLBIS(2-CHLOROACETANILIDE);Bis[4-(chloroacetylamino)phenyl] sulfone;4',4'''-Sulfonylbis(α-chloroacetanilide);N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
CBNumber: CB32217920
Molecular Formula: C16H14Cl2N2O4S
Formula Weight: 401.26
MOL File: 17328-16-4.mol

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N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Property

Melting point:: 191-192 °C
Boiling point:: 704.2±60.0 °C(Predicted)
Density: 1.504±0.06 g/cm3(Predicted)
storage temp.: -20°C (des.)
solubility: Soluble in DMSO (up to 50 mg/ml).
pka: 11.56±0.70(Predicted)
form: solid
color: Brown
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S718114
Product name: 4'',4''''-SULFONYLBIS(2-CHLOROACETANILIDE)
Purity: AldrichCPR
Packaging: 5MG
Price: $143
Updated: 2025/07/31

Cayman Chemical

Product number: 17718
Product name: TC-E 5003
Purity: ≥95%
Packaging: 25mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17718
Product name: TC-E 5003
Purity: ≥95%
Packaging: 50mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 17718
Product name: TC-E 5003
Purity: ≥98%
Packaging: 500mg
Price: $384
Updated: 2024/03/01

Cayman Chemical

Product number: 17718
Product name: TC-E 5003
Purity: ≥95%
Packaging: 100mg
Price: $130
Updated: 2024/03/01

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N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Chemical Properties,Usage,Production

Description

TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI₅₀s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.

Uses

NSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9.

in vivo

TC-E 5003 (0.5-2.0 mg, s.c., a single dose for 28 days) has an excellent tumor-suppressing effect in A549 tumor xenograft ICR mouse models ^[3].

Animal Model:	A549 tumor xenograft ICR mouse model^[3]
Dosage:	0.5-2.0 mg
Administration:	s.c., a single dose for 28 days
Result:	Achieved better antitumor effect in combination with INEI system in A549 tumor xenograft ICR mouse model.

IC 50

PRMT1

References

[1] ELISABETH-MARIA BISSINGER . Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1[J]. Bioorganic & Medicinal Chemistry, 2011, 19 12: Pages 3717-3731. DOI:10.1016/j.bmc.2011.02.032

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Preparation Products And Raw materials

Raw materials

Preparation Products

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