N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
- Product Name
- N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
- CAS No.
- 17328-16-4
- Chemical Name
- N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
- Synonyms
- TC-E 5003;N'-(Sulfonyldi-4;TC-E 5003 (NSC-30176);1-phenylene)bis(2-chloroacetamide);Bis[4-(chloroacetylamino)phenyl] sulfone;4',4'''-Sulfonylbis(α-chloroacetanilide);N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide);N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide);N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide);N,N'-[Sulfonylbis(4,1-phenylene)]bis(2-chloroacetamide)
- CBNumber
- CB32217920
- Molecular Formula
- C16H14Cl2N2O4S
- Formula Weight
- 401.26
- MOL File
- 17328-16-4.mol
N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Property
- Melting point:
- 191-192 °C
- Boiling point:
- 704.2±60.0 °C(Predicted)
- Density
- 1.504±0.06 g/cm3(Predicted)
- storage temp.
- -20°C (des.)
- solubility
- Soluble in DMSO (up to 50 mg/ml).
- pka
- 11.56±0.70(Predicted)
- form
- solid
- color
- Brown
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
N-Bromosuccinimide Price
- Product number
- S718114
- Product name
- 4'',4''''-SULFONYLBIS(2-CHLOROACETANILIDE)
- Purity
- AldrichCPR
- Packaging
- 5MG
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 17718
- Product name
- TC-E 5003
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17718
- Product name
- TC-E 5003
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 17718
- Product name
- TC-E 5003
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- 17718
- Product name
- TC-E 5003
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $130
- Updated
- 2024/03/01
N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Chemical Properties,Usage,Production
Description
TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.
Uses
NSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9.
References
1) Bissinger?et al. (2011),?Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem.,?19?3717
N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Preparation Products And Raw materials
Raw materials
Preparation Products
N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- +1-858-6993322
- Fax
- (+1)-858-876-1948
- info@accelachem.com
- Country
- United States
- ProdList
- 17982
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@apexbt.com
- Country
- United States
- ProdList
- 6251
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@focusbiomolecules.com
- Country
- United States
- ProdList
- 1284
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- chemicals@usbio.net
- Country
- United States
- ProdList
- 6214
- Advantage
- 80
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69