1-BROMO-2-NAPHTHALDEHYDE
- Product Name
- 1-BROMO-2-NAPHTHALDEHYDE
- CAS No.
- 3378-82-3
- Chemical Name
- 1-BROMO-2-NAPHTHALDEHYDE
- Synonyms
- 1-Bromo-2-naphthal;1-broMo-2-phthaldehyde;1-BROMO-2-NAPHTHALDEHYDE;1-Bromo-2-naphthaldehyde >1-BROMO-2-NAPHTHALDEHYDE 96+%;1-Bromo-2-naphthalenecarbaldehyde;1-BROMONAPHTHALENE-2-CARBALDEHYDE;1-Bromo-2-naphthalenecarboxaldehyde;1-bromo-2-naphthaldehyde crystalline;2-Naphthalenecarboxaldehyde, 1-bromo-
- CBNumber
- CB3225530
- Molecular Formula
- C11H7BrO
- Formula Weight
- 235.08
- MOL File
- 3378-82-3.mol
1-BROMO-2-NAPHTHALDEHYDE Property
- Melting point:
- 118°C
- Boiling point:
- 347℃
- Density
- 1.552
- Flash point:
- 120℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- crystals
- Appearance
- Off-white to yellow Solid
- BRN
- 2613639
- InChI
- InChI=1S/C11H7BrO/c12-11-9(7-13)6-5-8-3-1-2-4-10(8)11/h1-7H
- InChIKey
- CYGUXEZVBLMVRV-UHFFFAOYSA-N
- SMILES
- C1(Br)=C2C(C=CC=C2)=CC=C1C=O
- CAS DataBase Reference
- 3378-82-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 779636
- Product name
- 1-Bromo-2-naphthaldehyde
- Purity
- ≥96.0% (HPLC)
- Packaging
- 1g
- Price
- $148
- Updated
- 2025/07/31
- Product number
- B1647
- Product name
- 1-Bromo-2-naphthaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $88
- Updated
- 2025/07/31
- Product number
- B1647
- Product name
- 1-Bromo-2-naphthaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $260
- Updated
- 2025/07/31
- Product number
- B1647
- Product name
- 1-Bromo-2-naphthaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $779
- Updated
- 2025/07/31
- Product number
- B688455
- Product name
- 1-Bromo-2-naphthaldehyde
- Packaging
- 25g
- Price
- $1045
- Updated
- 2021/12/16
1-BROMO-2-NAPHTHALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Uses
1-Bromo-2-naphthaldehyde is used as a reagent in the synthesis of Hoveyda-Grubbs type metathesis catalysts which are used in cross olefin metathesis. 1-Bromo-2-naphthaldehyde is also used in the preparation of novel (-)-cercosporamide derivatives as potent selective PPARγ modulators.
Synthesis Reference(s)
The Journal of Organic Chemistry, 46, p. 4617, 1981 DOI: 10.1021/jo00335a076
Synthesis
37763-43-2
3378-82-3
General procedure for the synthesis of 1-bromo-2-naphthalene formaldehyde from 1-bromo-2-(bromomethyl)naphthalene: In a 2L reactor, 4-methylmorpholine N-oxide (61.4 g, 524 mmol), molecular sieves (200 g) and acetonitrile (1.2 L) were added and stirred for 30 min at 0 °C under nitrogen protection. Subsequently, 1-bromo-2-(bromomethyl)naphthalene (78 g, 262 mmol) was added and stirring was continued for 6 hours at room temperature. After completion of the reaction, the reaction mixture was filtered and the filtrate was washed with dichloromethane. The filtrate was concentrated and purified by column chromatography to afford 1-bromo-2-naphthaldehyde (45 g) in 73% yield.
References
[1] European Journal of Organic Chemistry, 2012, # 31, p. 6155 - 6164,10
[2] European Journal of Organic Chemistry, 2012, # 31, p. 6155 - 6164
[3] Tetrahedron Letters, 1994, vol. 35, # 48, p. 8985 - 8988
[4] Patent: US2018/72753, 2018, A1. Location in patent: Paragraph 0163-0164
[5] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 9, p. 1363 - 1378
1-BROMO-2-NAPHTHALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-BROMO-2-NAPHTHALDEHYDE manufacturers
- Product
- 1-Bromo-2-naphthaldehyde 3378-82-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- 1-BROMO-2-NAPHTHALDEHYDE 3378-82-3
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- customise
- Release date
- 2018-08-08