1-Methyl-L-proline methyl ester
- Product Name
- 1-Methyl-L-proline methyl ester
- CAS No.
- 27957-91-1
- Chemical Name
- 1-Methyl-L-proline methyl ester
- Synonyms
- Methyl (-)-hygrate;methyl methyl-L-prolinate;Pentanoylchloride,4-propyl-;N-Methyl-L-proline Methyl Ester;1-Methyl-L-proline methyl ester;L-Proline, 1-methyl-, methyl ester;methyl methyl-L-prolinate27957-91-1;Methyl 1-Methylpyrrolidine-2-carboxylate;(S)-Methyl 1-methylpyrrolidine-2-carboxylate;methyl (2S)-1-methylpyrrolidine-2-carboxylate
- CBNumber
- CB32262490
- Molecular Formula
- C7H13NO2
- Formula Weight
- 143.18
- MOL File
- 27957-91-1.mol
1-Methyl-L-proline methyl ester Property
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
- optical activity
- -31.37°(C=0.01 g/ml CHCL3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 0671AP
- Product name
- (S)-Methyl1-methylpyrrolidine-2-carboxylate
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- AS46141
- Product name
- (S)-Methyl 1-methylpyrrolidine-2-carboxylate
- Purity
- 97% ee
- Packaging
- 250mg
- Price
- $211
- Updated
- 2021/12/16
- Product number
- AS46141
- Product name
- (S)-Methyl 1-methylpyrrolidine-2-carboxylate
- Purity
- 97% ee
- Packaging
- 1g
- Price
- $429
- Updated
- 2021/12/16
- Product number
- 0671AP
- Product name
- (S)-Methyl1-methylpyrrolidine-2-carboxylate
- Packaging
- 5g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- AS46141
- Product name
- (S)-Methyl 1-methylpyrrolidine-2-carboxylate
- Purity
- 97% ee
- Packaging
- 5G
- Price
- $1380
- Updated
- 2021/12/16
1-Methyl-L-proline methyl ester Chemical Properties,Usage,Production
Synthesis
497-19-8
147-85-3
27957-91-1
1. L-proline (46 kg), paraformaldehyde (13.2 kg), palladium carbon (5%, 350 g) and methanol (158 kg) were added to a hydrogenation reactor. The hydrogenation reaction was carried out at 40 psi hydrogen pressure for 6 hours. 2. upon completion of the reaction, the reaction mixture was filtered and the filtrate was returned to the reaction vessel. 3. trimethyl orthoformate (170 kg) and thionyl chloride (171 kg) were added to the reaction vessel and the mixture was heated to reflux for 2 hours. 4. At the end of the reaction, the volatiles were removed by vacuum distillation. 5. The residue was dissolved in dichloromethane (215 kg), 10% aqueous sodium carbonate solution (360 kg) was added, vigorously mixed and the dichloromethane layer was separated. 6. The aqueous layer was extracted with dichloromethane (215kg) and the organic extracts were combined. 7. The organic phase was dried with anhydrous sodium sulfate (40 kg) and filtered. 8. The solvent was removed by vacuum distillation and the residue was distilled under high vacuum (10 mmHg) to afford methyl (S)-1-methylpyrrolidine-2-carboxylate (34.5 kg, 60% yield).
References
[1] Patent: US5424444, 1995, A
[2] Patent: US5516912, 1996, A
[3] Patent: US5508418, 1996, A
1-Methyl-L-proline methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-L-proline methyl ester Suppliers
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9341
- Advantage
- 55
- Tel
- 02136680027 15800370750
- 1706640024@qq.com
- Country
- China
- ProdList
- 485
- Advantage
- 56
- Tel
- 18086626237 18086626237
- Fax
- qq:2693528373
- 2693528373@qq.com
- Country
- China
- ProdList
- 2966
- Advantage
- 56
- Tel
- 028-028-37664989 15900794981
- jingzhichem@163.com
- Country
- China
- ProdList
- 536
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 88915
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66113011 19370895928
- Fax
- (7)02557626880
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15393
- Advantage
- 58
- Tel
- 021-4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52678
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30227
- Advantage
- 58
- Tel
- 17326194005
- 1873444526@qq.com
- Country
- China
- ProdList
- 495
- Advantage
- 58