Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol
- Product Name
- Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol
- CAS No.
- 136171-87-4
- Chemical Name
- Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol
- Synonyms
- Lobetyol;4,12-Tetradecadiene-8,10-diyne-1,6,7-triol;Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol
- CBNumber
- CB32289152
- Molecular Formula
- C14H18O3
- Formula Weight
- 234.29
- MOL File
- 136171-87-4.mol
Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol Property
- Boiling point:
- 468.3±45.0 °C(Predicted)
- Density
- 1.133±0.06 g/cm3(Predicted)
- pka
- 11.67±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- CFN92356
- Product name
- Lobetyol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $553
- Updated
- 2021/12/16
Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol Chemical Properties,Usage,Production
Uses
Lobetyol is a natural compound that can be isolated from Lobelia chinensis. Lobetyol induces apoptosis and cell cycle arrest in MKN45 cells. Lobetyol shows anti-virus, anti-inflammation and anti-tumor activity[1][2]. Lobetyol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
Lobetyol (0-10 mg/kg, Once per 3 days) suppresses tumor growth in MKN45 nude models[1].
| Animal Model: | BALB/C nude mice (6 weeks-old, injected intraperitoneally with MKN45 cells)[1] |
| Dosage: | 0, 2, 5, 10 mg/kg |
| Administration: | Once per 3 days |
| Result: | Suppressed tumor growth in MKN45 nude models. The protein levels of Ki67 in MKN45 cells were significantly decreased. Meanwhile, cleaved-caspase-3 positive MKN45 cells were found increased with the tendency of lobetyol concentrations in the study in vivo. |
IC 50
Bax; Bcl-2
References
[1] Shen J, et al. Lobetyol activate MAPK pathways associated with G1/S cell cycle arrest and apoptosis in MKN45 cells in vitro and in vivo. Biomed Pharmacother. 2016 Jul;81:120-127. DOI:10.1016/j.biopha.2016.03.046
[2] Xie Q, et al. The in vitro/in vivo metabolic pathways analysis of lobetyol, lobetyolin, and lobetyolinin, three polyacetylenes from Codonopsis Radix, by UHPLC-Q/TOF-MS and UHPLC-MS/MS. J Pharm Biomed Anal. 2023 Jan 20;223:115140. DOI:10.1016/j.jpba.2022.115140
Tetradeca-4,12-diene-8,10-diyne-1,6,7-triol Preparation Products And Raw materials
Raw materials
Preparation Products
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