L-trans-Pyrrolidine-2,4-dicarboxylic acid

Product Name: L-trans-Pyrrolidine-2,4-dicarboxylic acid
CAS No.: 64769-66-0
Chemical Name: L-trans-Pyrrolidine-2,4-dicarboxylic acid
Synonyms: 4-PDC;L-trans-2;Zinc03796127;L-TRANS-2,4-PDC;TRANS-4-CARBOXY-L-PROLINE;L-TRANS-4-CARBOXY-L-PROLINE;Ltrans2,4PDC,L trans 2,4 PDC;(2S,4R)-2,4-Pyrrolidinedicarboxylic acid;L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID;(2S,4R)-pyrrolidine-2,4-dicarboxylic acid
CBNumber: CB3230189
Molecular Formula: C6H9NO4
Formula Weight: 159.14
MOL File: 64769-66-0.mol

More

Less

L-trans-Pyrrolidine-2,4-dicarboxylic acid Property

Melting point:: 214-217oC
storage temp.: Store at RT
solubility: PBS (pH 7.2): 2 mg/ml
form: White solid.
color: White
Water Solubility: Soluble to 100 mM in water
InChI: InChI=1S/C6H9NO4/c8-5(9)3-1-4(6(10)11)7-2-3/h3-4,7H,1-2H2,(H,8,9)(H,10,11)/t3-,4+/m1/s1
InChIKey: NRSBQSJHFYZIPH-DMTCNVIQSA-N
SMILES: N1C[C@H](C(O)=O)C[C@H]1C(O)=O

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P7575
Product name: L-trans-Pyrrolidine-2,4-dicarboxylic acid
Purity: ≥98%
Packaging: 2mg
Price: $74.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: P7575
Product name: L-trans-Pyrrolidine-2,4-dicarboxylic acid
Purity: ≥98%
Packaging: 10mg
Price: $167.3
Updated: 2025/07/31

Cayman Chemical

Product number: 24268
Product name: L-trans-Pyrrolidine-2,4-dicarboxylic Acid
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24268
Product name: L-trans-Pyrrolidine-2,4-dicarboxylic Acid
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Tocris

Product number: 0298
Product name: L-trans-2,4-PDC
Purity: ≥97%(HPLC)
Packaging: 10
Price: $169
Updated: 2021/12/16

More

Less

L-trans-Pyrrolidine-2,4-dicarboxylic acid Chemical Properties,Usage,Production

Description

L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-2,4-PDC) is an inhibitor of L-glutamate transport (Ki = 4.6 μM in rat brain synaptosomes). It inhibits radioligand binding to NMDA receptors by 13% but has no effect on AMPA or kainate receptors when used at a concentration of 100 μM. L-trans-2,4-PDC is neurotoxic to astrocyte-rich and astrocyte-poor rat cortical cultures (EC50s = 320 and 50 μM, respectively), an effect that can be reversed by the NMDA antagonist MK-801 and glutamate-pyruvate transaminase but not the non-NMDA glutamate receptor antagonist CNQX. It induces efflux of the non-metabolizable glutamate analog [3H]-D-aspartate in an extracellular sodium-dependent manner. In vivo, L-trans-2,4-PDC (0.05-0.2 μg/side) prevents amphetamine-induced hyperlocomotion in a dose-dependent manner in rats when injected directly into the nucleus accumbens. It also increases bladder intercontraction interval (ICI) without affecting postvoid residual or basal pressure in rats.

Uses

L-trans-Pyrrolidine-2,4-dicarboxylic Acid is an inhibitor of the glutamate transporter EAAT.

Biological Activity

Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ .

storage

Store at RT

References

[1] RICHARD J. BRIDGES. Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer[J]. Journal of Medicinal Chemistry, 1991, 34 2: 717-725. DOI:10.1021/jm00106a037.
[2] Blitzblau, R., Gupta, S., Djali, S., et al. The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures. Eur. J. Neurosci. 8(9), 1840-1852 (1996).
[3] David, H.N., Thévenoux, A., and Abraini, J.H. Inhibition of the glutamate transporter by L-trans-PDC in the nucleus accumbens prevents the locomotor response to amphetamine. Neuropharmacology 41(3), 409-411 (2001).
[4] MASASHI HONDA. Supraspinal and spinal effects of L-trans-PDC, an inhibitor of glutamate transporter, on the micturition reflex in rats.[J]. Neurourology and Urodynamics, 2013, 32 7: 1026-1030. DOI:10.1002/nau.22351.

L-trans-Pyrrolidine-2,4-dicarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

L-trans-Pyrrolidine-2,4-dicarboxylic acid Suppliers

China 34 Europe 1 Germany 2 Japan 1 Switzerland 1 United Kingdom 4 United States 13 USA 1 Global 57

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Haiji Pharmaceutical Technology (Suzhou) Co., Ltd

Tel: 18012778619
Email: 3394205705@qq.com
Country: China
ProdList: 9848
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

64769-66-0, L-trans-Pyrrolidine-2,4-dicarboxylic acidRelated Search:

L-trans-Pyrrolidine-2,4-dicarboxylic acid TRANS-PYRROLIDINE-3,4-DICARBOXYLIC ACID DIMETHYL ESTER 4-METHYL-2-PYRROLIDINE CARBOXYLIC ACID L-Proline, 4-(hydroxymethyl)-, (4R)- (9CI) 3-Pyrrolidinecarboxylic acid 2,4-PYRROLIDINEDICARBOXYLIC ACID (2S, 4R)-NA-BOC-4-CARBOXYLIC ACID-PROLINE DIMETHYL ESTER TRITYL-L-TRANSPRO(4-COOME)-OME 4-methylglutamic acid (R)-Pyrrolidin-3-ylmethanol (2S,4R)-4-METHYLGLUTAMIC ACID FMOC-L-TRANSPRO[4-COOTBU]

L-TRANS-4-CARBOXY-L-PROLINE

L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID

L-TRANS-2,4-PDC

TRANS-4-CARBOXY-L-PROLINE

2,4-Pyrrolidinedicarboxylicacid,(2S,4R)-(9CI)

Zinc03796127

(2S,4R)-pyrrolidine-2,4-dicarboxylic acid

(2S,4R)-2,4-Pyrrolidinedicarboxylic acid

2,4-Pyrrolidinedicarboxylic acid, (2S,4R)-

4-PDC

L-trans-2

Ltrans2,4PDC,L trans 2,4 PDC

L-trans-Pyrrolidine-2,4-dicarboxylic acid, EAAT2, EAAT4 and EAAT5 inhibitor

<sc>L</sc>-<i>trans</i>-Pyrrolidine-2,4-dicarboxylic acid

64769-66-0

PYRROLE

Glutamate receptor