MEPANIPYRIM Property

Melting point:

125-126° (Maeno); also reported as 132.8° (Hayashi)

Boiling point:

418.2±47.0 °C(Predicted)

Density 

1.16±0.1 g/cm3(Predicted)

vapor pressure 

2.32 x l0^-5 Pa (20 °C)

Flash point:

131 °C

storage temp. 

0-6°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

4.5 (est. base)

Water Solubility 

3.1 mg l^-1(20 °C)

color 

White to Off-White

LogP

3.280

EPA Substance Registry System

Mepanipyrim (110235-47-7)

Safety

Hazard Codes 

N,Xn

Risk Statements 

51/53-50/53-40

Safety Statements 

60-61-46-36/37

RIDADR 

UN3077 9/PG 3

WGK Germany 

2

RTECS 

UV6261540

Toxicity

LD50 in mice, rats, bobwhite, mallard (mg/kg): >5000, >5000, >2250, >2250 orally; in rats (mg/kg): >2000 dermally; LC50 in bluegill, rainbow trout (mg/l): 3.8, 3.1 (Maeno)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

MEPANIPYRIM Chemical Properties,Usage,Production

Uses

Mepanipyrim is a non-systemic fungicide that provides preventative control of diseases in pome fruits (scab), vines, strawberries, tomatoes and cucumbers (grey mould) and peaches (brown rots) caused by Botrytis cinerea, Venturia inaequaris and Monilinia fructicola.

Uses

Mepanipyrim is an anilinopyrimidine fungicide which have been used in the management of fungal diseases in strawberries.

Uses

Agricultural fungicide.

Definition

ChEBI: A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying additional methyl and 1-propynyl substituents at positions 4 and 6 respectively. A fungicide used to control a wide range of diseases including grey mou d on strawberries, tomatoes and cucumabers, and scab on apples and pears.

Metabolic pathway

By tomato seedlings, 14C-mepanipyrim is biotransformed via the pathways including elimination of the phenyl group, hydroxylation of the propynyl moiety, and hydroxylation at the phenyl ring to yield several kinds of metabolite, and 2- and 4-[4-methyl-6- (1-propynyl)pyrimidin-2-ylamino]phenols, 1-(2-anilino-6- methylpyrimidin-4-yl)-2-propanol, and 4-methyl-6-(1- propynyl)pyrimidin-2-ylamine are tentatively identified as major metabolites. In soils under laboratory conditions, 14C-mepanipyrim undergoes degradation to give the degradation products and the main pathway is elimination of the phenyl group.

Degradation

Mepanipyrim (1) is stable to hydrolytic degradation in the pH range 4-9 with a DT₅₀ >1 year. It decomposed rapidly in water when exposed to light (DT₅₀ 13 days) (PM).