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2,4-Dibromo-3-methylthiophene

Product Name
2,4-Dibromo-3-methylthiophene
CAS No.
53119-66-7
Chemical Name
2,4-Dibromo-3-methylthiophene
Synonyms
2,4-Dibromo-3-methylthiophene
CBNumber
CB32332076
Molecular Formula
C5H4Br2S
Formula Weight
255.95826
MOL File
53119-66-7.mol
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Hazard and Precautionary Statements (GHS)

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2,4-Dibromo-3-methylthiophene Chemical Properties,Usage,Production

Preparation

Synthesis of 2,4-Dibromo-3-methylthiophene: A mixture of 3-methylthiphene (50.0 g, 0.509 mol), glacial AcOH (400 mL) and NaOAc (132 g, 1.60 mol) was stirred and heated to 60°C. Bromine (260 g, 1.63 mol) was then added dropwise at such a rate that kept the temperature below 85°C . The mixture was heated at 85°C for 5 h to complete the conversion to 2,4,5-tribromo-3-methylthiophene, then water (85 g) was added and the reaction temperature was dropped to 60°C. Zinc dust (48.1 g, 0.73 mol) was carefully added in 5-10 g portions so as to keep the temperature below 85°C. The mixture was heated to 100°C for 8 h, then cooled to 25°C. Water (350 mL) and hexanes (500 mL) were then added. The mixture was stirred for 30 min, the organic layer was separated, washed with water (150 mL), then saturated NaHCO3 solution (150 mL), then concentrated to give an orange oil. This oil was distilled (b.p. 80°C @ 0.3 mm Hg) through a 6” jacketed Vigreux column to give 107 g (82% wt.) of a yellow oil which slowly solidified. GC area % analysis showed the product to be a mixture of 2,4-dibromo-3-methylthiophene (89%), 4,5-dibromo-3-methylthiophene (9%), and 4-bromo-3-methylthiophene (2%).

2,4-Dibromo-3-methylthiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dibromo-3-methylthiophene Suppliers

Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-400-8210725 4008210725
Email
malulu@leyan.com
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China
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40000
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Zhuhai Aobokai Biomedical Technology Co., Ltd.
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400-0628126 15976997964;
Email
sales-team@aobchem.com.cn
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China
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50195
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Beijing Famozi Pharmaceutical Technology Co., Ltd
Tel
13331045123
Email
2728639891@qq.com
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China
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9935
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Woerjiming (Beijing) Technology Development Institute
Tel
18610294897
Email
414752910@qq.com
Country
China
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1296
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58

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