GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA

Product Name: GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA
CAS No.: 99026-77-4
Chemical Name: GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA
Synonyms: GKGAGLSLSRFSWGA;[ALA107]-MBP (104-118);[ALA107]-MBP FRAGMENT 104-118;[Ala107]-MBP (104-118) acetate Salt;[Ala107]-Myelin Basic Protein (104-118);[ALA107]-MYELIN BASIC PROTEIN FRAGMENT 104-118;[Ala¹⁰⁷]-Myelin Basic Protein Fragment 104-118;GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA;L-Alanine, glycyl-L-lysylglycyl-L-alanylglycyl-L-leucyl-L-seryl-L-leucyl-L-seryl-L-arginyl-L-phenylalanyl-L-seryl-L-tryptophylglycyl- (9CI);(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[(2-aminoacetyl)amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]propanoic acid
CBNumber: CB3236444
Molecular Formula: C67H104N20O19
Formula Weight: 1493.67
MOL File: 99026-77-4.mol

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GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA Property

storage temp.: −20°C
solubility: Soluble to 1 mg/ml in 10% acetonitrile
form: solid
color: White
biological source: human
Sequence: H-Gly-Lys-Gly-Ala-Gly-Leu-Ser-Leu-Ser-Arg-Phe-Ser-Trp-Gly-Ala-OH

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1900
Product name: [Ala107]-MBP(104-118)
Packaging: 1
Price: $137
Updated: 2021/12/16

ApexBio Technology

Product number: B5218
Product name: [Ala107]-MBP(104-118)
Packaging: 1mg
Price: $308
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000844
Product name: [ALA107]-MYELIN BASIC PROTEIN (104-118)
Purity: 95.00%
Packaging: 1MG
Price: $697.34
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000844
Product name: [ALA107]-MYELIN BASIC PROTEIN (104-118)
Purity: 95.00%
Packaging: 5MG
Price: $1206.98
Updated: 2021/12/16

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GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA Chemical Properties,Usage,Production

Uses

[Ala107]MBP(104-118) is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 46-145 μM[1].

Biological Activity

[ala107]-mbp (104-118) is a non-competitive inhibitor of pkc and synthetic peptide analog of bovine myelin basic protein (mbp) with ic50 value of 46 - 145 mm.1. substrate specificity of phospholipid/ca2+ dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein. turner et al. j.biol.chem., 1985;260:115032. synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase c). su et al. biochem.biophys.res.commun., 1986;134:78

Biochem/physiol Actions

[Ala107]-Myelin Basic Protein Fragment 104-118 is an inhibitor of protein kinase C.

IC 50

PKC: 46-145 μM (IC₅₀)

References

[1] Su HD, et, al. Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C). Biochem Biophys Res Commun. 1986 Jan 14; 134(1): 78-84. DOI:10.1016/0006-291x(86)90529-2

GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA Preparation Products And Raw materials

Raw materials

Preparation Products

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GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA Suppliers

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99026-77-4, GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALARelated Search:

GLY-LYS-GLY-ARG-GLY-LEU-SER-LEU-SER-ALA-PHE-SER-TRP-GLY-ALA GLY-LYS-GLY-ARG-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA

GLY-LYS-GLY-ALA-GLY-LEU-SER-LEU-SER-ARG-PHE-SER-TRP-GLY-ALA

[ALA107]-MBP (104-118)

[ALA107]-MBP FRAGMENT 104-118

[ALA107]-MYELIN BASIC PROTEIN FRAGMENT 104-118

(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[(2-aminoacetyl)amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]propanoic acid

[Ala107]-Myelin Basic Protein (104-118)

L-Alanine, glycyl-L-lysylglycyl-L-alanylglycyl-L-leucyl-L-seryl-L-leucyl-L-seryl-L-arginyl-L-phenylalanyl-L-seryl-L-tryptophylglycyl- (9CI)

GKGAGLSLSRFSWGA

[Ala107]-MBP (104-118) acetate Salt

[Ala<sup>107</sup>]-Myelin Basic Protein Fragment 104-118

99026-77-4

C67H104N20O19

Protein Kinase