PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL
- Product Name
- PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL
- CAS No.
- 474711-89-2
- Chemical Name
- PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL
- Synonyms
- BUTTPARK 85\04-05;Piperazine-1-carboxylic acid amid;1-piperazinecarboxamide hydrochloride;PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL;Piperazine-1-carboxamide hydrochloride;PIPERAZINE-1-CARBOXYLIC ACID AMIDE X HCL;PIPERAZINE-1-CARBOXYLIC ACID AMIDE HYDROCHLORIDE;PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL ISO 9001：2015 REACH
- CBNumber
- CB3240920
- Molecular Formula
- C5H12ClN3O
- Formula Weight
- 165.62
- MOL File
- 474711-89-2.mol
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Property
- Melting point:
- 221-224°C
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H11N3O.ClH/c6-5(9)8-3-1-7-2-4-8;/h7H,1-4H2,(H2,6,9);1H
- InChIKey
- UVYKKFKLOUEFAR-UHFFFAOYSA-N
- SMILES
- C(N1CCNCC1)(=O)N.Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B448905
- Product name
- Piperazine-1-carboxamideHydrochloride
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B448905
- Product name
- Piperazine-1-carboxamideHydrochloride
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H53-5-03
- Product name
- Piperazine-1-carboxamide hydrochloride
- Purity
- 98.0%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 4H53-5-03
- Product name
- Piperazine-1-carboxamide hydrochloride
- Purity
- 98.0%
- Packaging
- 5G
- Price
- $467
- Updated
- 2021/12/16
- Product number
- 4107AE
- Product name
- Piperazine-1-carboxylicacidamidehydrochloride
- Packaging
- 10g
- Price
- $764
- Updated
- 2021/12/16
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Chemical Properties,Usage,Production
Uses
Piperazine-1-carboxamide Hydrochloride is used in preparation of heteroaromatic derivatives as PDE4 inhibitors.
Synthesis
883554-88-9
474711-89-2
General procedure for the synthesis of piperazine-1-amide hydrochloride from tert-butyl 4-carbamoylpiperazine-1-carboxylate: To a dichloromethane (DCM, 2 mL) solution of tert-butyl 4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) was added an ethyl acetate (EtOAc) solution of hydrochloric acid (4 M, 2 mL). The reaction mixture was stirred at room temperature for 30 min and then concentrated under reduced pressure to give piperazine-1-amide hydrochloride as a white solid (0.16 g, 100% yield). The product was characterized by 1H NMR (600 MHz, CD3OD): δ 3.71-3.73 (m, 4H), 3.25-3.27 (m, 4H); MS-ESI: m/z 130.10 [M + H - HCl]+.
References
[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00403
[2] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1050; 1054-1056
[3] Patent: EP1593679, 2005, A1. Location in patent: Page/Page column 59
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL manufacturers
- Product
- PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL 474711-89-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-19