3,3-DIETHOXY-1-PROPANOL
- Product Name
- 3,3-DIETHOXY-1-PROPANOL
- CAS No.
- 16777-87-0
- Chemical Name
- 3,3-DIETHOXY-1-PROPANOL
- Synonyms
- 3,3-diethoxypropanol;3,3-DIETHOXY-1-PROPANOL;3,3-Diethoxy-propan-1-ol;1-Propanol, 3,3-diethoxy-;3,3-Diethoxy-1-propanol 98%;3-hydroxypropionaldehyde diethyl acetal
- CBNumber
- CB3243815
- Molecular Formula
- C7H16O3
- Formula Weight
- 148.2
- MOL File
- 16777-87-0.mol
3,3-DIETHOXY-1-PROPANOL Property
- Boiling point:
- 90-93 °C/14 mmHg (lit.)
- Density
- 0.941 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.421(lit.)
- Flash point:
- 196 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- pka
- 15.05±0.10(Predicted)
- color
- Clear colorless
- InChI
- InChI=1S/C7H16O3/c1-3-9-7(5-6-8)10-4-2/h7-8H,3-6H2,1-2H3
- InChIKey
- ASERXEZXVIJBRO-UHFFFAOYSA-N
- SMILES
- C(O)CC(OCC)OCC
- LogP
- 0.789 (est)
Safety
- WGK Germany
- 3
- HS Code
- 29094980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 273252
- Product name
- 3,3-Diethoxy-1-propanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $29.5
- Updated
- 2025/07/31
- Product number
- 273252
- Product name
- 3,3-Diethoxy-1-propanol
- Purity
- 98%
- Packaging
- 5g
- Price
- $182
- Updated
- 2025/07/31
- Product number
- D442995
- Product name
- 3,3-Diethoxy-1-propanol
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD166713
- Product name
- 3,3-Diethoxypropan-1-ol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD166713
- Product name
- 3,3-Diethoxypropan-1-ol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
3,3-DIETHOXY-1-PROPANOL Chemical Properties,Usage,Production
Uses
3,3-Diethoxy-1-propanol was used in the synthesis of α-acetal-poly(ethylene glycol) via reaction with potassium napthalide and ethylene oxide inside an UniLab Glovebox.
Synthesis
10601-80-6
16777-87-0
Tetrahydrofuran (THF) was dehydrated through 4Å molecular sieves overnight and set aside. Under nitrogen protection, 2.2 kg of dehydrated THF was added to a 5 L four-necked flask and cooled to below 10 °C. 50 g of lithium aluminum hydride was slowly added, followed by dropwise addition of 250 g of ethyl 3,3-diethoxypropionate, controlling the internal temperature not to exceed 10 °C. After the dropwise addition was completed, the temperature was raised to 20°C and the reaction was carried out for 1 hour. After completion of the reaction, 420 g of distilled water was added and stirred for 2 h. The filtrate was filtered through No. 2 filter paper and the cake was washed with 1.1 kg of THF. The filtrate was concentrated at 40 °C to give 213 g of crude 3,3-diethoxy-1-propanol (abbreviated as 33DEP). 200g of crude 33DEP was taken in a 5L four-necked flask, 1kg of hexane was added and stirred for 1 hour (Step A). Add 1kg of 0.1M phosphate buffer (pH 7.5), stir for 20 minutes and transfer to a 5L separatory funnel and leave to stratify. After separating the aqueous layer, the hexane layer was returned to the flask and the aqueous layer was recovered by repeating the addition of 1 kg of 0.1 M phosphate buffer (pH 7.5), stirring for 20 minutes, and again transferring to a partitioning funnel for stationary partitioning (Step B). The combined aqueous layer was transferred back to a 5L four-necked flask, 2kg of chloroform was added, stirred for 30 minutes, transferred to a 5L partition funnel and left to stratify for 15 minutes. The chloroform layer was recovered and the aqueous layer was repeated once with 2 kg chloroform extraction and the chloroform layers were combined (Step C). The chloroform layer was concentrated at 40°C and residual solvent was removed by nitrogen bubbling. 20g of 4Å molecular sieve was added and filtered after stirring for 5 h to give 188 g of 33DEP. 150 g of 33DEP was taken in a 300 mL four neck flask and subjected to reduced pressure distillation. The first fraction was collected at 0.4 kPa, bath temperature of 38°C, internal temperature of 36°C, and temperature at the top of the tower of 33°C. Subsequently, the bath temperature was gradually increased, and the main fraction was collected at 0.2 kPa, bath temperature of 58 °C, internal temperature of 55 °C, and temperature of the top of the tower of 54 °C, and the temperature of the top of the tower was controlled not to exceed 60 °C, and finally 138 g of the main fraction was obtained (Step D). The main fraction was analyzed by GC and the results are shown in Table 1.
References
[1] Patent: US2012/277477, 2012, A1. Location in patent: Page/Page column 5
[2] Acta Chemica Scandinavica (1947-1973), 1973, vol. 27, p. 239 - 250
[3] Patent: US4634773, 1987, A
3,3-DIETHOXY-1-PROPANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,3-DIETHOXY-1-PROPANOL manufacturers
- Product
- 3,3-DIETHOXY-1-PROPANOL 16777-87-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-23
- Product
- 3,3-DIETHOXY-1-PROPANOL 16777-87-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1
- Release date
- 2018-08-06