7-ISOPROPYLISATIN
- Product Name
- 7-ISOPROPYLISATIN
- CAS No.
- 57816-97-4
- Chemical Name
- 7-ISOPROPYLISATIN
- Synonyms
- 7-ISOPROPYLISATIN;UKRORGSYN-BB BBV-030970;7-Isopropylindoline-2,3-dione;7-(1-Methylethyl)-1H-indole-2,3-dione;1H-Indole-2,3-dione, 7-(1-methylethyl)-
- CBNumber
- CB32449855
- Molecular Formula
- C11H11NO2
- Formula Weight
- 189.21
- MOL File
- 57816-97-4.mol
7-ISOPROPYLISATIN Property
- Melting point:
- 196-198 °C(Solv: dichloromethane (75-09-2))
- Density
- 1.200±0.06 g/cm3(Predicted)
- pka
- 9.81±0.20(Predicted)
- InChI
- InChI=1S/C11H11NO2/c1-6(2)7-4-3-5-8-9(7)12-11(14)10(8)13/h3-6H,1-2H3,(H,12,13,14)
- InChIKey
- XWJSENVAAAAHBN-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2C(C)C)C(=O)C1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I873468
- Product name
- 7-Isopropyl-1H-indole-2,3-dione
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- I873468
- Product name
- 7-Isopropyl-1H-indole-2,3-dione
- Packaging
- 500mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- CHM0384086
- Product name
- 7-ISOPROPYLISATIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.61
- Updated
- 2021/12/16
- Product number
- 4708CT
- Product name
- 7-Isopropylindoline-2,3-dione
- Packaging
- 2.5g
- Price
- $853
- Updated
- 2021/12/16
- Product number
- 177953
- Product name
- 7-Isopropyl-1H-indole-2,3-dione
- Packaging
- 0.500g
- Price
- $160
- Updated
- 2021/12/16
7-ISOPROPYLISATIN Chemical Properties,Usage,Production
Uses
7-Isopropyl-1H-indole-2,3-dione is used in the synthetic preparation of 2-aminoquinazoline derivatives as PLK1 inhibitor useful in treatment of various diseases.
Synthesis
To concentrated sulfuric acid at 80° C. was added 2-hydroxyimino-N-(2-isopropyl-phenyl)-acetamide in several small portions over 10 minutes. After addition it was heated at 80° C. for 30 minutes., then poured into ice. Filtration, washing with water, and drying under vacuum over P2O5 provided 2.974 g (84%) of 7-Isopropyl-1H-indole-2,3-dione as a solid.
7-ISOPROPYLISATIN Preparation Products And Raw materials
Raw materials
Preparation Products
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