6-IODOINDOLE
- Product Name
- 6-IODOINDOLE
- CAS No.
- 115666-47-2
- Chemical Name
- 6-IODOINDOLE
- Synonyms
- 6-Iodo-1H-indole;6-IODOINDOLE;6-IODOONDOLE;1H-Indole, 6-iodo-
- CBNumber
- CB32452233
- Molecular Formula
- C8H6IN
- Formula Weight
- 243.04
- MOL File
- 115666-47-2.mol
6-IODOINDOLE Property
- Melting point:
- 111.0-111.5℃
- Boiling point:
- 341.7±15.0 °C(Predicted)
- Density
- 1.960±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 16.20±0.30(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I717000
- Product name
- 6-Iodoindole
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- I717000
- Product name
- 6-Iodoindole
- Packaging
- 1g
- Price
- $825
- Updated
- 2021/12/16
- Product number
- 126708
- Product name
- 6-Iodo-1H-indole
- Purity
- >95%
- Packaging
- 1g
- Price
- $1044
- Updated
- 2021/12/16
- Product number
- HCH0359855
- Product name
- 6-IODO-1H-INDOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.12
- Updated
- 2021/12/16
- Product number
- Z3913
- Product name
- 6-Iodo-1H-indole
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
6-IODOINDOLE Chemical Properties,Usage,Production
Uses
6-Iodoindole is an intermediate used to prepare linear tripeptides for right-hand segments of complestatin.
Synthesis
52415-29-9
115666-47-2
General procedure for the synthesis of 6-iodo-1H-indole from 6-bromo-1H-indole: To a dioxane solution (30 mL) of 6-bromo-1H-indole (3.00 g, 15.3 mmol) under nitrogen protection were sequentially added NaI (4.59 g, 30.6 mmol), CuI (290 mg, 1.53 mmol) and N,N'-dimethyl ethylenediamine (0.35 mL). The reaction mixture was purged with nitrogen for 5 min to remove oxygen. Subsequently, the reaction mixture was stirred overnight in an oil bath at 110 °C under nitrogen atmosphere. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the organic solvent. EtOAc and water were added to the residue to separate the organic and aqueous phases. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, concentrated and purified by column chromatography (eluent: pure petroleum ether) to afford the target compound 6-iodo-1H-indole (2.1 g, 57% yield). Mass spectrum (ESI) m/z: 244.0 [M + H]+.
References
[1] Angewandte Chemie - International Edition, 2013, vol. 52, # 2, p. 650 - 654
[2] Angew. Chem., 2013, vol. 125, # 2, p. 678 - 682,5
[3] Chemical Communications, 2016, vol. 52, # 60, p. 9442 - 9445
[4] Chemistry - A European Journal, 2017, vol. 23, # 72, p. 18216 - 18224
[5] Angewandte Chemie - International Edition, 2015, vol. 54, # 1, p. 263 - 266
6-IODOINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-IODOINDOLE manufacturers
- Product
- 6-IODOINDOLE 115666-47-2
- Price
- US $9.85/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 m
- Release date
- 2024-11-29
- Product
- 6-IODOINDOLE 115666-47-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09