BENZYL 2-BROMOETHYLCARBAMATE
- Product Name
- BENZYL 2-BROMOETHYLCARBAMATE
- CAS No.
- 53844-02-3
- Chemical Name
- BENZYL 2-BROMOETHYLCARBAMATE
- Synonyms
- NSC 128581;Benzyl (2-bromoethyl);N-Cbz-3-broMoethylaMine;N-CBZ-2-BROMOETHYLAMINE;BENZYL 2-BROMOETHYLCARBAMATE;Benzyl N-(2-broMoethyl)carbaMate;2-Bromoethylamine, N-CBZ protected;2-Benzyloxycarbonylaminoethyl bromide;N-Benzyloxycarbonyl-2-bromoethylamine;N-Benzyloxycarbonyl-3-bromoethylamine
- CBNumber
- CB32452763
- Molecular Formula
- C10H12BrNO2
- Formula Weight
- 258.11
- MOL File
- 53844-02-3.mol
BENZYL 2-BROMOETHYLCARBAMATE Property
- Melting point:
- 45 °C
- Boiling point:
- 361.1±35.0 °C(Predicted)
- Density
- 1.428
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 11.55±0.46(Predicted)
- Appearance
- Off-white to light yellow <45°C Solid,>45°C Liquid
- InChI
- InChI=1S/C10H12BrNO2/c11-6-7-12-10(13)14-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13)
- InChIKey
- HREXFDIZSAUXBO-UHFFFAOYSA-N
- SMILES
- C(OCC1=CC=CC=C1)(=O)NCCBr
Safety
- HS Code
- 2921199990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B678840
- Product name
- N-(2-Bromoethyl)-phenylmethylestercarbamicacid
- Packaging
- 5g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- FB144005
- Product name
- Benzyl (2-bromoethyl)carbamate
- Packaging
- 2g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 4656-9-X1
- Product name
- 2-Bromoethylamine, N-Cbz protected
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- Z4847
- Product name
- N-Cbz-2-Bromoethylamine
- Packaging
- 5g
- Price
- $67
- Updated
- 2021/12/16
- Product number
- FB144005
- Product name
- Benzyl (2-bromoethyl)carbamate
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
BENZYL 2-BROMOETHYLCARBAMATE Chemical Properties,Usage,Production
Uses
N-??(2-??Bromoethyl)??-phenylmethyl ester carbamic acid is known to be use in organic reactions as a reactant or reagent.
Synthesis
2576-47-8
501-53-1
53844-02-3
General procedure for the synthesis of N-Cbz-3-bromoethylamine from 2-bromoethylamine hydrobromide and benzyl chloroformate: 2-bromoethylamine hydrobromide (12.000 g; 58.56 mmol; 1.0 eq.), which was cooled to 0 °C, was dissolved in dioxane (60 ml), and an aqueous 1 M NaOH solution (117.2 ml; 117.20 mmol; 2.0 equivalent), followed by dropwise addition of benzyl chloroformate (8.4 ml; 58.8 mmol; 1.0 eq.) for a controlled period of 10 min. The reaction mixture was continued to be stirred at 0 °C for 10 min under nitrogen protection, then raised to room temperature and stirred for 13 hours. After completion of the reaction, ether (300 ml) was added for extraction and the organic layer was washed with deionized water (75 ml) and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated to dryness under reduced pressure to give N-benzyloxycarbonyl-3-bromoethylamine as a colorless oil (15.020 g; 99% yield).LC-MS analysis: retention time t R = 0.95 min; [M + H]+: no ionization peak was observed.
References
[1] Journal of Medicinal Chemistry, 1981, vol. 24, # 4, p. 408 - 428
[2] Patent: US2011/105514, 2011, A1. Location in patent: Page/Page column 21
[3] Patent: WO2009/156951, 2009, A2. Location in patent: Page/Page column 47-48
[4] Chemical Communications, 2010, vol. 46, # 17, p. 2983 - 2985
[5] Journal of Organic Chemistry, 2000, vol. 65, # 26, p. 8979 - 8987
BENZYL 2-BROMOETHYLCARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BENZYL 2-BROMOETHYLCARBAMATE manufacturers
- Product
- BENZYL 2-BROMOETHYLCARBAMATE 53844-02-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-10