4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE
- Product Name
- 4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE
- CAS No.
- 911461-47-7
- Chemical Name
- 4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE
- Synonyms
- 4,6-DICHLOROPYRIMIDINE-5-CARBOXAMIDE;4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE;5-Pyrimidinecarboxamide, 4,6-dichloro-;4,6-Dichloro-pyrimidine-5-carboxylic acid amide
- CBNumber
- CB32452844
- Molecular Formula
- C5H3Cl2N3O
- Formula Weight
- 192
- MOL File
- 911461-47-7.mol
4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE Property
- Melting point:
- 202-204 °C(Solv: isopropanol (67-63-0))
- Boiling point:
- 311.9±42.0 °C(Predicted)
- Density
- 1.620±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.39±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5217AC
- Product name
- 4,6-Dichloropyrimidine-5-carboxamide
- Packaging
- 100mg
- Price
- $88
- Updated
- 2021/12/16
- Product number
- ACI-05451
- Product name
- 4,6-Dichloro-pyrimidine-5-carboxylicacidamide
- Purity
- 95%+
- Packaging
- 1g
- Price
- $259.55
- Updated
- 2021/12/16
- Product number
- ACI-05451
- Product name
- 4,6-Dichloro-pyrimidine-5-carboxylicacidamide
- Purity
- 95%+
- Packaging
- 1g
- Price
- $259.55
- Updated
- 2021/12/16
- Product number
- CT3358
- Product name
- 4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE
- Purity
- >95%
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- CM129472
- Product name
- 4,6-dichloropyrimidine-5-carboxamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $292
- Updated
- 2021/12/16
4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE Chemical Properties,Usage,Production
Synthesis
87600-97-3
911461-47-7
4,6-Dichloropyrimidine-5-carbonyl chloride (36 g, 170 mmol) was dissolved in tetrahydrofuran (200 mL) under ammonia atmosphere and the reaction was stirred at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) until the complete disappearance of the raw material. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the resulting residue was partitioned with ethyl acetate (300 mL) and water (100 mL). The aqueous phase was further extracted with ethyl acetate (100 mL x 2). All organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 4,6-dichloropyrimidine-5-carboxamide (27.2 g, yield: 83.2%) as a yellow solid. Mass spectrum (ESI, positive ion mode) m/z: 191.9 [M + H]+; 1H NMR (600 MHz, CDCl3) δ (ppm): 8.85 (s, 1H), 6.23 (br.s, 1H), 5.96 (br.s, 1H).
References
[1] Patent: US2015/87658, 2015, A1. Location in patent: Paragraph 0682; 0683; 0684
[2] Patent: CN104513235, 2017, B. Location in patent: Paragraph 0728; 0729; 0730; 0731; 0999; 01000-01001
[3] Russian Chemical Bulletin, 2005, vol. 54, # 8, p. 1907 - 1914
4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
4,6-DICHLORO-5-PYRIMIDINECARBOXAMIDE Suppliers
- Tel
- --
- Fax
- --
- enquiries@acints.com
- Country
- United States
- ProdList
- 4893
- Advantage
- 58