ChemicalBook > CAS DataBase List > 1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE

Product Name
1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
CAS No.
866396-34-1
Chemical Name
1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
Synonyms
DPPI 1C HCL;DPPI 1C HYDROCHLORIDE;Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem;2,5-Pyrrolidinedicarbonitrile, 1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]acetyl]-, (2R,5S)-rel-;1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
CBNumber
CB32453447
Molecular Formula
C14H20N4O2
Formula Weight
276.33
MOL File
866396-34-1.mol
More
Less

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Property

storage temp. 
Desiccate at RT
solubility 
Soluble in DMSO > 10 mM
form 
White solid
color 
white
Water Solubility 
PBS: 20mg/mL
ethanol: 20mg/mL
water: 20mg/mL
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
317641
Product name
Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem
Packaging
5mg
Price
$294
Updated
2023/01/07
Tocris
Product number
2783
Product name
DPPI1chydrochloride
Purity
≥98%(HPLC)
Packaging
1
Price
$116
Updated
2021/12/16
Tocris
Product number
2783
Product name
DPPI1chydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$248
Updated
2021/12/16
Usbiological
Product number
255195
Product name
DPPI 1c hydrochloride
Packaging
1mg
Price
$360
Updated
2021/12/16
ApexBio Technology
Product number
A4425
Product name
DPPI1chydrochloride
Packaging
10mg
Price
$380
Updated
2021/12/16
More
Less

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

DPP4-In is an active compound.

General Description

An orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 μM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.

Biological Activity

Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC 50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC 50 > 30 μ M). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.

References

[1] High mobility group box 1 contributes to wound healing induced by inhibition of dipeptidylpeptidase 4 in cultured keratinocytes

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE Suppliers

China 21 United Kingdom 1 United States 6 Global 28
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58

866396-34-1, 1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDERelated Search:

(S)-Pyrrolidine-2-carbonitrile hydrochloride (S)-PYRROLIDINE-2-CARBONITRILE (R)-PYRROLIDINE-2-CARBONITRILE HYDROCHLORIDE 1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE

  • 1-[[[(1-HYDROXYMETHYL)CYCLOPENTYL]AMINO]ACETYL]-2,5-CIS-PYRROLIDINEDICARBONITRILE HYDROCHLORIDE
  • DPPI 1C HYDROCHLORIDE
  • DPPI 1C HCL
  • Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem
  • 2,5-Pyrrolidinedicarbonitrile, 1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]acetyl]-, (2R,5S)-rel-
  • 866396-34-1
  • C14H20N4O2HCl