TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE
- Product Name
- TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE
- CAS No.
- 152537-03-6
- Chemical Name
- TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE
- Synonyms
- 1-Boc-3-(hydroxyethyl)aze...;N-Boc-2-(azetidin-3-yl)ethanol;1-Boc-3-(hydroxyethyl)azetidine;1-Boc-3-(2-hydroxyethyl)azetidine;(2E)-3-(5-methyl-13-furyl)acrylic acid;tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxyl;TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE;3-(2-hydroxyethyl)-1-azetidinecarboxylic acid tert-butyl ester;tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate - [B0298];1-Azetidinecarboxylic acid, 3-(2-hydroxyethyl)-, 1,1-dimethy...
- CBNumber
- CB32454772
- Molecular Formula
- C10H19NO3
- Formula Weight
- 201.26
- MOL File
- 152537-03-6.mol
TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE Property
- Boiling point:
- 287.4±13.0 °C(Predicted)
- Density
- 1.092±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 15.05±0.10(Predicted)
- form
- oil
- color
- Yellow
- InChI
- InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-8(7-11)4-5-12/h8,12H,4-7H2,1-3H3
- InChIKey
- PIEFOIGZJZFQQJ-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC(CCO)C1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B810060
- Product name
- tert-Butyl3-(2-Hydroxyethyl)azetidine-1-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B810060
- Product name
- tert-Butyl3-(2-Hydroxyethyl)azetidine-1-carboxylate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H56-1-PJ
- Product name
- 1-Boc-3-(hydroxyethyl)azetidine
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- Y7610
- Product name
- tert-Butyl3-(2-hydroxyethyl)azetidine-1-carboxylate
- Packaging
- 1g
- Price
- $211
- Updated
- 2021/12/16
- Product number
- 068634
- Product name
- tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate
- Purity
- >95%
- Packaging
- 250mg
- Price
- $341
- Updated
- 2021/12/16
TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
183062-96-6
152537-03-6
General procedure for the synthesis of tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate from N-Boc-3-azetidineacetic acid: 2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid (3.91 g) was dissolved in tetrahydrofuran (THF, 18.17 mL), and the solution was cooled to 0 °C. The solution was then purified by stirring. Under stirring, ethylborane (1 M solution of THF, 54.5 mL) was added slowly and dropwise. The reaction mixture was stirred at 0 °C for 1 hour. Subsequently, water was added slowly and dropwise to quench the unreacted borane. The reaction mixture was diluted with ethyl acetate (EtOAc, 150 mL) and washed with deionized water (100 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate as a clear oil in 100% yield. The product was confirmed by 1H NMR (CDCl3): δ 4.0 (t, 2H), 3.60 (m, 4H), 2.65 (m, 1H), 1.85 (m, 2H), 1.43 (s, 9H).
References
[1] Patent: WO2011/86125, 2011, A1. Location in patent: Page/Page column 61
[2] Patent: WO2010/141809, 2010, A1. Location in patent: Page/Page column 33
[3] Patent: WO2017/27684, 2017, A1. Location in patent: Paragraph 00148; 00254
[4] Patent: WO2018/140809, 2018, A1. Location in patent: Paragraph 00454
TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE Suppliers
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View Lastest Price from TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE manufacturers
- Product
- tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate 152537-03-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.7%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
- Product
- TERT-BUTYL 3-(2-HYDROXYETHYL)AZETIDINE-1-CARBOXYLATE 152537-03-6
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-03-23