TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE

Product Name: TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE
CAS No.: 733757-89-6
Chemical Name: TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE
Synonyms: 6-Boc-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine;tert-butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydropyrazolo[3,4-c]pyridine-6-carboxylate;tert-Butyl 3-(trifluoroMethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate;TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE;3-Trifluoromethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester;"3-TrifluoroMethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridine-6-carboxylic acid tert-butyl ester";6H-Pyrazolo[3,4-c]pyridine-6-carboxylic acid, 1,4,5,7-tetrahydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester
CBNumber: CB32455562
Molecular Formula: C12H16F3N3O2
Formula Weight: 291.27
MOL File: 733757-89-6.mol

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TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE Property

Boiling point:: 368.4±42.0 °C(Predicted)
Density: 1.326±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.49±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 1402AC
Product name: tert-Butyl3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate
Packaging: 250mg
Price: $157
Updated: 2021/12/16

Matrix Scientific

Product number: 188158
Product name: tert-Butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate
Packaging: 1g
Price: $353
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0361673
Product name: TERT-BUTYL-3-(TRIFLUOROMETHYL)-4,5-DIHYDRO-1H-PYRAZOLO-[3,4-C]PYRIDINE-6(7H)-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $505.64
Updated: 2021/12/16

AK Scientific

Product number: 1402AC
Product name: tert-Butyl3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate
Packaging: 5g
Price: $868
Updated: 2021/12/16

Matrix Scientific

Product number: 188158
Product name: tert-Butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate
Packaging: 5g
Price: $998
Updated: 2021/12/16

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TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

647863-25-0

733757-89-6

The general procedure for the synthesis of tert-butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate using tert-butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate as a starting material was as follows: to a solution of 1-tert-butyloxycarbonyl-4-(trifluoroacetyl)-3-piperidinone (23.6 g, 0.08 mol) (4.16 ml, 0.086 mol) was added to a solution of ethanol (250 ml) with hydrazine monohydrate (4.16 ml, 0.086 mol). The reaction mixture was stirred at 50°C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The concentrated residue was partitioned between ethyl acetate and saturated brine. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was recrystallized by ethyl acetate/n-pentane mixed solvent to afford the target compound tert-butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate as a light yellow solid (6.5 g, 28% yield). The product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 11.13 (1H, broad single peak), 4.40 (2H, multiple peaks), 3.66 (2H, multiple peaks), 2.70 (2H, multiple peaks), 1.48 (9H, single peak); the LC/MS analysis showed a retention time of 2.90 min, and a mass spectrometry (ES-) m/z 290 ([M- H]-, calculated value of C12H16F3N3O2 has a molecular weight of 291).

References

[1] Patent: US2010/137276, 2010, A1. Location in patent: Page/Page column 17-18
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 1, p. 78 - 94
[3] Patent: WO2008/113795, 2008, A1. Location in patent: Page/Page column 42
[4] Patent: WO2008/148832, 2008, A1. Location in patent: Page/Page column 40

TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE Suppliers

China 38 India 1 United Kingdom 1 United States 5 Global 45

PharmaBlock Sciences (Nanjing),Inc.

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SuZhou ShiYa Biopharmaceuticals, Inc.

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SuZhou ShiYa Biopharmaceuticals, Inc.

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Amadis Chemical Company Limited

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Cochemical Ltd.

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View Lastest Price from TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: tert-Butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate 733757-89-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-02-04

733757-89-6, TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATERelated Search:

3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE

TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE

tert-Butyl 3-(trifluoroMethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate

"3-TrifluoroMethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridine-6-carboxylic acid tert-butyl ester"

3-Trifluoromethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

6H-Pyrazolo[3,4-c]pyridine-6-carboxylic acid, 1,4,5,7-tetrahydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester

6-Boc-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine

tert-butyl 3-(trifluoromethyl)-1,4,5,7-tetrahydropyrazolo[3,4-c]pyridine-6-carboxylate

733757-89-6