5-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE
- Product Name
- 5-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE
- CAS No.
- 73387-52-7
- Chemical Name
- 5-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE
- Synonyms
- 5-(4-Bromophenyl)-1-methylpyrazole;5-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE;1H-Pyrazole, 5-(4-bromophenyl)-1-methyl-
- CBNumber
- CB32459308
- Molecular Formula
- C10H9BrN2
- Formula Weight
- 237.1
- MOL File
- 73387-52-7.mol
5-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE Property
- Melting point:
- 58℃
- Boiling point:
- 331.6±17.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.69±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 3H32-9-AV
- Product name
- 5-(4-Bromophenyl)-1-methyl-1H-pyrazole
- Packaging
- 1g
- Price
- $311
- Updated
- 2021/12/16
- Product number
- 8791CT
- Product name
- 5-(4-Bromophenyl)-1-methyl-1H-pyrazole
- Packaging
- 5g
- Price
- $625
- Updated
- 2021/12/16
- Product number
- HCH0098862
- Product name
- 5-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $879.25
- Updated
- 2021/12/16
- Product number
- HCH0098862
- Product name
- 5-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1879.76
- Updated
- 2021/12/16
- Product number
- CM187912
- Product name
- 5-(4-Bromophenyl)-1-methyl-1H-pyrazole
- Purity
- 95+%
- Packaging
- 10g
- Price
- $687
- Updated
- 2021/12/16
5-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE Chemical Properties,Usage,Production
Synthesis
99-90-1
4637-24-5
60-34-4
73387-52-7
4-Bromoacetophenone (20.0 g, 0.10 mol) was mixed with N,N-dimethylformamide dimethyl acetal (28.5 mL, 0.20 mol) in N,N-dimethylformamide (12 mL) and heated to 110 °C for 4 hours. During the reaction, the resulting methanol and water (6.2 mL total) were removed by distillation. After completion of the reaction, the mixture was cooled to 25 °C. Subsequently, methyl tert-butyl ether (100 mL) and methylhydrazine (21.2 mL, 0.40 mol) were added to the mixture and stirred overnight at room temperature. The reaction mixture was washed sequentially with 1M aqueous ammonium chloride (3 x 40 mL) and water (40 mL). The organic phase was dried by azeotropic distillation through a Dean-Stark apparatus or, as an alternative, through anhydrous magnesium sulfate column. The dried solution was filtered through a silica gel column (60 g) and the product was eluted from the column with methyl tert-butyl ether. The eluates containing the product were combined and concentrated to about 70 mL by distillation. Heptane (120 mL) was added to the concentrate and distillation was continued until the tank temperature reached 98.4°C. Approximately 100 mL of the distillate was collected. The remaining mixture was cooled to 40°C, inoculated with crystalline seed and maintained at this temperature for 30 minutes to induce crystallization. Subsequently, the mixture was slowly cooled to 0°C over 90 minutes and held at 0°C for 30 minutes. The solid was collected by filtration, washed (3 times) with pre-cooled (0 °C) heptane and dried over a filter to give a cream-colored crystalline solid (16.3 g, 68% yield).The nuclear magnetic resonance (NMR) data of 5-(4-bromophenyl)-1-methyl-1H-pyrazole were in agreement with Alternative 1 .
References
[1] Patent: WO2009/69044, 2009, A1. Location in patent: Page/Page column 67-68
[2] Patent: WO2009/69044, 2009, A1. Location in patent: Page/Page column 67
[3] Patent: WO2016/16421, 2016, A1. Location in patent: Page/Page column 52
5-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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