5-(BROMOMETHYL)-2-METHOXYPYRIDINE
- Product Name
- 5-(BROMOMETHYL)-2-METHOXYPYRIDINE
- CAS No.
- 128632-03-1
- Chemical Name
- 5-(BROMOMETHYL)-2-METHOXYPYRIDINE
- Synonyms
- 5-(BROMOMETHYL)-2-METHOXYPYRIDINE;Pyridine, 5-(bromomethyl)-2-methoxy-
- CBNumber
- CB32459717
- Molecular Formula
- C7H8BrNO
- Formula Weight
- 202.05
- MOL File
- 128632-03-1.mol
5-(BROMOMETHYL)-2-METHOXYPYRIDINE Property
- Boiling point:
- 249.0±25.0 °C(Predicted)
- Density
- 1.484±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.49±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- Y7368
- Product name
- 5-(Bromomethyl)-2-methoxypyridine
- Packaging
- 250mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- CM248697
- Product name
- 5-(Bromomethyl)-2-methoxypyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $248
- Updated
- 2021/12/16
- Product number
- A180366
- Product name
- 5-(Bromomethyl)-2-methoxypyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $287
- Updated
- 2021/12/16
- Product number
- CD11300264
- Product name
- 5-(Bromomethyl)-2-methoxypyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $325
- Updated
- 2021/12/16
- Product number
- CM248697
- Product name
- 5-(Bromomethyl)-2-methoxypyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $842
- Updated
- 2021/12/16
5-(BROMOMETHYL)-2-METHOXYPYRIDINE Chemical Properties,Usage,Production
Synthesis
58584-63-7
128632-03-1
(6-Methoxypyridin-3-yl)methanol (250 mg, 1.797 mmol, commercially available from e.g. Fluorochem) was used as starting material, which was dissolved in chloroform (20 mL) in a 50 mL round bottom flask. Phosphorus tribromide (0.188 mL, 1.989 mmol) was slowly added dropwise to the reaction system at 0 °C. After the reaction was completed, the reaction was stopped and the reaction was completed. After the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was washed with water (3 x 30 mL) and the organic layer was separated. The organic phases were combined, washed with saturated saline (30 mL), filtered through a hydrophobic glass stock and concentrated under reduced pressure to remove the solvent. The resulting oily crude product was dissolved in dichloromethane and purified by column chromatography on a Biage Isolera SNAP 25g silica gel with an elution gradient of 0-4% cyclohexane/ethyl acetate. The fraction containing the target product was collected and concentrated under reduced pressure to give 5-(bromomethyl)-2-methoxypyridine (160 mg, 0.792 mmol, 44% yield) as a colorless oil.The results of LCMS (2 mM formic acid) analysis were: retention time (Rt) = 0.93 min, [M+H]+ = 202.
References
[1] Journal of Labelled Compounds and Radiopharmaceuticals, 2007, vol. 50, # 5-6, p. 613 - 615
[2] Patent: WO2017/37116, 2017, A1. Location in patent: Page/Page column 76
5-(BROMOMETHYL)-2-METHOXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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