3-(BENZYLOXY)CYCLOBUTANONE

Product Name: 3-(BENZYLOXY)CYCLOBUTANONE
CAS No.: 30830-27-4
Chemical Name: 3-(BENZYLOXY)CYCLOBUTANONE
Synonyms: 3-(Benzyloxy)cyclobutan-1-one;3-(BENZYLOXY)CYCLOBUTANONE;3- (benzyloxy) -1-butanone;3-(Benzyloxy)cyclobutan-1...;Cyclobutanone, 3-(benzyloxy)-;3-phenylmethoxycyclobutan-1-one;Cyclobutanone, 3-(phenylmethoxy)-;3-(Benzyloxy)cyclobutan-1-one 97+%;3-(benzyloxy)-2,2-dichlorocyclobutanone;3-(BENZYLOXY)CYCLOBUTANONE###30830-27-4
CBNumber: CB32460661
Molecular Formula: C11H12O2
Formula Weight: 176.21
MOL File: 30830-27-4.mol

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3-(BENZYLOXY)CYCLOBUTANONE Property

Boiling point:: 285℃
Density: 1.11
refractive index: 1.5225
Flash point:: 126℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: clear liquid
color: Colorless to Yellow
InChI: InChI=1S/C11H12O2/c12-10-6-11(7-10)13-8-9-4-2-1-3-5-9/h1-5,11H,6-8H2
InChIKey: GPPSQLLIFNWNSB-UHFFFAOYSA-N
SMILES: C1(=O)CC(OCC2=CC=CC=C2)C1

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Safety

WGK Germany: WGK 3
HS Code: 2914500090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Irrit. 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: KOB0140
Product name: 3-(Benzyloxy)cyclobutan-1-one
Packaging: 1 g
Price: $191
Updated: 2026/04/30

Sigma-Aldrich

Product number: KOB0139
Product name: 1-(1H-Indol-3-yl)-2-methylpropan-2-amine
Packaging: 1G
Price: $352
Updated: 2026/04/30

TCI Chemical

Product number: B6029
Product name: 3-(Benzyloxy)cyclobutanone
Packaging: 200MG
Price: $33
Updated: 2026/04/30

TCI Chemical

Product number: B6029
Product name: 3-(Benzyloxy)cyclobutanone
Packaging: 1G
Price: $113
Updated: 2026/04/30

TRC

Product number: B286895
Product name: 3-(Benzyloxy)cyclobutanone
Packaging: 1g
Price: $140
Updated: 2021/12/16

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3-(BENZYLOXY)CYCLOBUTANONE Chemical Properties,Usage,Production

Uses

3-(Benzyloxy)cyclobutanone is used as a reactant for the synthesis of cyclobutyl derivatives of 2''-deoxyadenosine 5''-triphosphate as inhibitors of HIV-1 reverse transcriptase.

Synthesis

917887-34-4

30830-27-4

The general procedure for the synthesis of 3-(benzyloxy)-1-cyclobutanone from the compound (CAS: 917887-34-4) was as follows: 26.5 L of diethyl ether was added to a 30-35 L reactor and the reactor was water cooled at the beginning of the addition. 1.064 kg of compound (VII) was added to the reactor. 0.932 L of perchloric acid (60%) was pre-diluted with 0.664 L of water and added slowly to the reactor over 20-30 minutes at 10°C. After addition of the acid, cooling was stopped and the reaction was stirred vigorously overnight at about 20°C. The reaction was quenched by the addition of 900 g of NaHCO3 dissolved in 8 L of water until the pH was about 7. The aqueous phase was discarded and the reaction mixture was washed with an additional 7 L of water. The ether was removed under vacuum, 2 L of toluene was added, and the crude mixture was azeotropically dried. The crude product was diluted to about 2 L with toluene and loaded onto a silica gel pad. The pad was wet packed and pre-eluted with toluene. For the separation of 1.5 kg batches, a silica gel pad with a diameter of 40 cm and a height of 22 cm was used. After the crude product was applied to the pad, it was eluted with eluent in the following order: 3 x 10 L toluene; 9 x 10 L toluene: ethyl acetate (95:5). The product grades were collected and the solvent was evaporated under vacuum. High vacuum was required to remove the last 5% of toluene. Final isolation gave 533 g of product (yield = 77%).GC analysis showed 95% product purity. The 1H NMR (500 MHz, CDCl3) data for compound (VIII) were as follows: δH 7.40-7.29 (m, 5H), 4.53 (s, 2H), 4.38 (tt, J = 6.6, 4.7Hz, 1H), 3.3-3.1 (m, 4H).

References

[1] Patent: WO2013/11115, 2013, A1. Location in patent: Paragraph 00059-00061
[2] Bulletin of the Chemical Society of Japan, 1984, vol. 57, # 6, p. 1637 - 1642
[3] Patent: US2009/233903, 2009, A1. Location in patent: Page/Page column 58
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 12, p. 4064 - 4067
[5] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 3, p. 643 - 652

3-(BENZYLOXY)CYCLOBUTANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(BENZYLOXY)CYCLOBUTANONE Suppliers

Americas 1 China 215 Europe 1 India 3 Japan 1 United Kingdom 2 United States 12 Global 235

Jiangsu Synthesis Bio-Tech Co., LTD

Tel: 13761708290
Email: 13761708290@163.com
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Shanghai Shanyuan pharmaceutical technology co., LTD

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Aikon International Limited

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Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
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Nanjing Habo Medical Technology Co., Ltd.

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Shandong Mingde Biotechnology Co., Ltd

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Shandong Jiuyue Biotechnology Co., Ltd.

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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Energy Chemical

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View Lastest Price from 3-(BENZYLOXY)CYCLOBUTANONE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3-(Benzyloxy)cyclobutanone 30830-27-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(BENZYLOXY)CYCLOBUTANONE 30830-27-4
Price: US $4458.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1T
Release date: 2020-07-06

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(BENZYLOXY)CYCLOBUTANONE 30830-27-4
Price: US $4458.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1T
Release date: 2020-07-06

30830-27-4, 3-(BENZYLOXY)CYCLOBUTANONERelated Search:

4-BENZYLOXYPROPIOPHENONE 3-(BENZYLOXY)CYCLOBUTANONE Cyclobutanone

3-(BENZYLOXY)CYCLOBUTANONE

1-(Benzyloxy)-3-oxocyclobutane, {[(3-Oxocyclobut-1-yl)oxy]methyl}benzene

3-(Benzyloxy)cyclobutan-1-one 97+%

3- (benzyloxy) -1-butanone

3-(BENZYLOXY)CYCLOBUTANONE###30830-27-4

Cyclobutanone, 3-(benzyloxy)-

3-phenylmethoxycyclobutan-1-one

3-(Benzyloxy)cyclobutan-1...

https://www.chemicalbook.com/productlist.aspxcbn=CB32460661

Cyclobutanone, 3-(phenylmethoxy)-

3-(benzyloxy)-2,2-dichlorocyclobutanone

1-(1<i>H</i>-Indol-3-yl)-2-methylpropan-2-amine

3-(Benzyloxy)cyclobutan-1-one

30830-27-4