4-Fluoro-N-methoxy-N-methylbenzamide
- Product Name
- 4-Fluoro-N-methoxy-N-methylbenzamide
- CAS No.
- 116332-54-8
- Chemical Name
- 4-Fluoro-N-methoxy-N-methylbenzamide
- Synonyms
- SKL799;UORO-N-METHOXY-N-METHYL;4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE;N-Methyl-N-methoxy-4-fluorobenzamide;4-Fluoro-N-methyl-N-methoxybenzamide;Benzamide, 4-fluoro-N-methoxy-N-methyl-;N-Methoxy-N-methyl-4-fluorobenzaldehyde;4-Fluoro-N-methoxy-N-methylbenzamide 98%;4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE(WXFC0878)
- CBNumber
- CB32463642
- Molecular Formula
- C9H10FNO2
- Formula Weight
- 183.18
- MOL File
- 116332-54-8.mol
4-Fluoro-N-methoxy-N-methylbenzamide Property
- Boiling point:
- 301.6±25.0 °C(Predicted)
- Density
- 1.179±0.06 g/cm3(Predicted)
- refractive index
- 1.51
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- White to Yellow to Green
- InChI
- InChI=1S/C9H10FNO2/c1-11(13-2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3
- InChIKey
- DSUFRPVVBZLHPI-UHFFFAOYSA-N
- SMILES
- C(N(OC)C)(=O)C1=CC=C(F)C=C1
Safety
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F1194
- Product name
- 4-Fluoro-N-methoxy-N-methylbenzamide
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- F1194
- Product name
- 4-Fluoro-N-methoxy-N-methylbenzamide
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $171
- Updated
- 2025/07/31
- Product number
- F532253
- Product name
- 4-Fluoro-n-methoxy-n-methylbenzamide
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC250001
- Product name
- 4-Fluoro-N-methoxy-N-methylbenzamide
- Purity
- 98%
- Packaging
- 25g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- 4748-3-01
- Product name
- 4-Fluoro-N-methoxy-N-methylbenzamide
- Purity
- 98%
- Packaging
- 25g
- Price
- $112
- Updated
- 2021/12/16
4-Fluoro-N-methoxy-N-methylbenzamide Chemical Properties,Usage,Production
Description
4-Fluoro-N-methoxy-N-methylbenzamide is a fluorinated aromatic. As an organofluorine compound, it can synthesise pyridyl heterocycles and photochromic compounds. 4-Fluoro-N-methoxy-N-methylbenzamide can form exocyclic fluorinating agents by reacting with iodides. It can form complexes with copper or zinc as a ligand and convert metal hydroxides into metal carbonyls as a carbonylative agent. As a phosphine, it can be converted into carboxylic acids through hydrolysis or oxidation.
Synthesis
6638-79-5
403-43-0
116332-54-8
The general procedure for the synthesis of 4-fluoro-N-methoxy-N-methylbenzamide from dimethylhydroxylamine hydrochloride and 4-fluorobenzoyl chloride was as follows: 4-fluorobenzoyl chloride (15 g, 94.6 mmol) and N,O-dimethylhydroxylamine hydrochloride (10.1 g, 104 mmol) were dissolved in chloroform (200 mL) and stirred at room temperature. The reaction solution was cooled to 0 °C and pyridine (17.3 mL, 230 mmol) was added slowly. The reaction mixture was gradually warmed to room temperature and stirring was continued for 1 hour. After the reaction was completed, the mixture was poured into saturated sodium chloride solution (300 mL). The organic layer was separated and the aqueous layer was extracted with dichloromethane (3 x 100 mL). The organic layers were combined, washed with water (3 x 50 mL), dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The crude product was purified by vacuum distillation to afford the colorless liquid 4-fluoro-N-methoxy-N-methylbenzamide in 96% yield with a boiling point of 120 °C (0.3 mmHg). The characteristic absorption peaks of its infrared spectrum were 583, 905, 918, 1262, 1375, 1508, 1582, 1630, 2972, 3274 cm^-1; the NMR hydrogen spectral data were δH 3.34 (3H, s, CH3), 3.52 (3H, s, OCH3), 7.08 (2H, m, Ar-H), and 7.73 (2H, m , Ar-H).
References
[1] Bioorganic and Medicinal Chemistry, 1997, vol. 5, # 1, p. 49 - 64
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 5, p. 1352 - 1357
[3] Organic and Biomolecular Chemistry, 2013, vol. 11, # 20, p. 3337 - 3340
[4] Journal of Organic Chemistry, 2007, vol. 72, # 15, p. 5828 - 5831
[5] Patent: US5616596, 1997, A
4-Fluoro-N-methoxy-N-methylbenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-N-methoxy-N-methylbenzamide manufacturers
- Product
- 4-FLUORO-N-METHOXY-N-METHYLBENZAMIDE 116332-54-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-06