7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE
Application- Product Name
- 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE
- CAS No.
- 76006-11-6
- Chemical Name
- 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE
- Synonyms
- o[3,4-c]pyridine;7-chloro-1H-pyrazolo[3;7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE;1H-Pyrazolo[3,4-c]pyridine, 7-chloro-;7-Chloro-1H-pyrazolo[3,4-c]pyridine 97%;7-chloro-1h-pyrazole and [3,4-c] pyridine
- CBNumber
- CB32464270
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 76006-11-6.mol
7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE Property
- Melting point:
- 161-163℃
- Boiling point:
- 357.5±22.0 °C(Predicted)
- Density
- 1.531
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.87±0.40(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C380853
- Product name
- 7-Chloro-1H-pyrazolo[3,4-c]pyridine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H32-5-12
- Product name
- 7-Chloro-1H-pyrazolo[3,4-c]pyridine
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- FC144098
- Product name
- 7-Chloro-1H-pyrazolo[3,4-c]pyridine
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- Y5102
- Product name
- 7-Chloro-1H-pyrazolo[3,4-c]pyridine
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- FC144098
- Product name
- 7-Chloro-1H-pyrazolo[3,4-c]pyridine
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE Chemical Properties,Usage,Production
Application
7-Chloro-1H-pyrazolo[3,4-C]pyridine can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development and chemical production processes.
Synthesis
133627-45-9
76006-11-6
Step 1: A solution of sodium nitrite (7.36 g, 107 mmol) in water (30 mL) was slowly added dropwise to a solution of 2-chloro-3-amino-4-methylpyridine (10.14 g, 71.1 mmol) and potassium acetate (9.02 g, 92 mmol) in acetic acid (200 mL) while keeping the internal temperature below 13 °C. After the dropwise addition was completed, the reaction mixture was allowed to slowly warm to room temperature and stirred continuously for 66 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was alkalized with saturated sodium bicarbonate solution. Subsequently, the solid product was collected by filtration and washed with distilled water. The resulting solid was stirred in ethyl acetate overnight and filtered again. The filtrate was combined with the organic extract, evaporated to dryness and adsorbed on silica gel, and purified by fast column chromatography (using 120 g silica gel, eluent ethyl acetate: hexane, gradient from 0:1 to 1:1), resulting in a white crystalline solid product, 7-chloro-1H-pyrazolo[3,4-c]pyridine (4.99 g, 46% yield). Mass spectrometry analysis showed m/z = 153.9, 155.9 [M + H]+, which corresponds to the theoretically calculated value of molecular weight 153 for C6H4ClN3.
References
[1] Patent: US2014/249104, 2014, A1. Location in patent: Page/Page column
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 2398 - 2404
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 2398 - 2404
[4] Patent: WO2012/93101, 2012, A1. Location in patent: Page/Page column 154
[5] Patent: WO2014/2052, 2014, A1. Location in patent: Page/Page column 51
7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE manufacturers
- Product
- 7-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE 76006-11-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25