2，4-dihydroxyl-6-fluoroquinazoline
- Product Name
- 2，4-dihydroxyl-6-fluoroquinazoline
- CAS No.
- 88145-90-8
- Chemical Name
- 2，4-dihydroxyl-6-fluoroquinazoline
- Synonyms
- 6-Fluoroquinazoline-2,4-diol;2,4-Dihydroxy-6-fluoroquinazoline;6-fluoro-1H-quinazoline-2,4-dione;2，4-dihydroxyl-6-fluoroquinazoline;6-fluoro-2,4(1H,3H)-Quinazolinedione;6-Fluoroquinazoline-2,4(1H,3H)-dione;2,4(1H,3H)-Quinazolinedione, 6-fluoro-;6-Fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione
- CBNumber
- CB32469886
- Molecular Formula
- C8H5FN2O2
- Formula Weight
- 180.14
- MOL File
- 88145-90-8.mol
2，4-dihydroxyl-6-fluoroquinazoline Property
- Melting point:
- >300 °C
- Density
- 1.434±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.09±0.20(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- D454523
- Product name
- 2,4-Dihydroxyl-6-fluoroquinazoline
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- X5048
- Product name
- 2,4-Dihydroxy-6-fluoroquinazoline
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 118767
- Product name
- 6-Fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione
- Purity
- >95%
- Packaging
- 500mg
- Price
- $172
- Updated
- 2021/12/16
- Product number
- PC910745
- Product name
- 2,4-Dihydroxyl-6-fluoroquinazoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 118767
- Product name
- 6-Fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione
- Purity
- >95%
- Packaging
- 1g
- Price
- $232
- Updated
- 2021/12/16
2，4-dihydroxyl-6-fluoroquinazoline Chemical Properties,Usage,Production
Synthesis
124-38-9
61272-77-3
88145-90-8
Under argon protection, 2-amino-5-fluorobenzonitrile (1 mmol) was dissolved in DMSO-d6 (1 mL), catalyst (0.01 mmol) was added and placed in a stainless steel autoclave. After sealing the autoclave, the mixture was heated to 110 °C and carbon dioxide was poured in until the pressure reached 2 MPa. The cyclization reaction was completed by magnetically stirring the mixture at 110 °C for 3 h. After the reaction was completed, the autoclave was heated to 110 °C and carbon dioxide was poured in. At the end of the reaction, the autoclave was cooled in an ice bath followed by slow pressure release. The chemical yield of 6-fluoroquinazoline-2,4(1H,3H)-dione was determined by 1H NMR analysis using 3,5-dimethoxybenzyl alcohol as an internal standard. For the scale-up experiment (6 mmol 2-amino-5-fluorobenzonitrile, 6 mL DMSO), the carboxycyclization reaction was carried out under the same conditions. After completion of the reaction, the same was cooled and depressurized and the reaction mixture was poured into water (60 mL). The precipitate was collected by filtration, washed sequentially with water and ether, and finally dried under vacuum at 35 °C for 15 h to give pure 6-fluoroquinazoline-2,4(1H,3H)-dione.
References
[1] RSC Advances, 2015, vol. 5, # 7, p. 5032 - 5037
[2] Tetrahedron, 2018, vol. 74, # 24, p. 2914 - 2920
[3] Green Chemistry, 2014, vol. 16, # 6, p. 3142 - 3148
[4] European Journal of Organic Chemistry, 2016, vol. 2016, # 14, p. 2555 - 2559
[5] Patent: CN105153048, 2017, B. Location in patent: Paragraph 0124; 00125
2，4-dihydroxyl-6-fluoroquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
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