2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid
- Product Name
- 2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid
- CAS No.
- 69999-15-1
- Chemical Name
- 2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid
- Synonyms
- 2-(2,3-Dihydrobenzofuran-5-yl);5-Benzofuranacetic acid, 2,3-dihydro-a-hydroxy-;5-Benzofuranacetic acid, 2,3-dihydro-α-hydroxy-;2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid;2-(2,3-dihydrobenzofuran-5-yl)-2-hydroxyacetic acid;2-(2,3-dihydro-5-benzofuranyl)-2-hydroxyacetic acid;2-(2,3-dihydro-1-benzofuran-5-yl)-2-hydroxyacetic acid
- CBNumber
- CB32470336
- Molecular Formula
- C10H10O4
- Formula Weight
- 194.18
- MOL File
- 69999-15-1.mol
2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid Property
- Boiling point:
- 407.2±33.0 °C(Predicted)
- Density
- 1.435
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.53±0.11(Predicted)
N-Bromosuccinimide Price
- Product number
- 0840AC
- Product name
- 2-(2,3-Dihydrobenzofuran-5-yl)-2-hydroxyaceticacid
- Packaging
- 250mg
- Price
- $266
- Updated
- 2021/12/16
- Product number
- CHM0385794
- Product name
- 2,3-DIHYDRO-ALPHA-HYDROXY-5-BENZOFURANACETIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.64
- Updated
- 2021/12/16
- Product number
- CM159955
- Product name
- 2-(2,3-dihydrobenzofuran-5-yl)-2-hydroxyaceticacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- CD11070215
- Product name
- 2-(2,3-Dihydrobenzofuran-5-yl)-2-hydroxyaceticacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $397
- Updated
- 2021/12/16
- Product number
- 69999151
- Product name
- 2-(2,3-Dihydrobenzofuran-5-yl)-2-hydroxyaceticacid
- Packaging
- 1g
- Price
- $413.03
- Updated
- 2021/12/16
2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid Chemical Properties,Usage,Production
Synthesis
71922-83-3
69999-15-1
2-Amino-2-(2,3-dihydrobenzofuran-5-yl)acetic acid (200 mg, 1.04 mmol) was used as starting material and dissolved in glacial acetic acid (250 mg, 4.14 mmol). An aqueous solution of sodium nitrite (145 mg, 2.08 mmol) was added dropwise (~5 mL) under stirring. Subsequently, additional glacial acetic acid (1 mL) was added and the reaction mixture was heated to 65 °C and kept at this temperature for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with water and extracted several times with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the target product 2-(2,3-dihydrobenzofuran-5-yl)-2-hydroxyacetic acid in about 65% yield. The product was confirmed by NMR hydrogen spectrum (DMSO-D6): δ 7.15 (m, 3H), 5.18 (d, 1H), 4.78 (t, 2H), 3.34 (t, 2H).
References
[1] Patent: US4138397, 1979, A
[2] Patent: US4229575, 1980, A
[3] Journal of Medicinal Chemistry, 1980, vol. 23, # 4, p. 405 - 412
2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid manufacturers
- Product
- 2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid 69999-15-1
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 2,3-Dihydro-alpha-hydroxy-5-benzofuranacetic acid 69999-15-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000KG
- Release date
- 2019-09-04