(4-fluorotetrahydro-2H-pyran-4-yl)methanamine
- Product Name
- (4-fluorotetrahydro-2H-pyran-4-yl)methanamine
- CAS No.
- 883442-46-4
- Chemical Name
- (4-fluorotetrahydro-2H-pyran-4-yl)methanamine
- Synonyms
- (4-fluorooxan-4-yl)methanol;4-HydroxyMethyl-4-fluoro-...;4-Fluorotetrahydropyran-4-methanol;(4,4-Dimethyl-cyclohexyl)-methanol;(4-Fluorotetrahydropyran-4-yl)methanol;2H-Pyran-4-methanol, 4-fluorotetrahydro-;4-HydroxyMethyl-4-fluoro-tetrahydro-2H-pyran;(4-fluorotetrahydro-2H-pyran-4-yl)methanamine
- CBNumber
- CB32470518
- Molecular Formula
- C6H11FO2
- Formula Weight
- 134.15
- MOL File
- 883442-46-4.mol
(4-fluorotetrahydro-2H-pyran-4-yl)methanamine Property
- Boiling point:
- 198℃
- Density
- 1.12
- Flash point:
- 100℃
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F596215
- Product name
- (4-Fluorotetrahydro-2H-pyran-4-yl)methanol
- Packaging
- 2.5g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- 2H10-3-11
- Product name
- (4-Fluorooxan-4-yl)methanol
- Packaging
- 1g
- Price
- $890
- Updated
- 2021/12/16
- Product number
- 2H10-3-11
- Product name
- (4-Fluorooxan-4-yl)methanol
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- CHM0292122
- Product name
- (4-FLUOROTETRAHYDRO-2H-PYRAN-4-YL)METHANAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.62
- Updated
- 2021/12/16
- Product number
- CM108874
- Product name
- (4-fluorooxan-4-yl)methanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $515
- Updated
- 2021/12/16
(4-fluorotetrahydro-2H-pyran-4-yl)methanamine Chemical Properties,Usage,Production
Uses
(4-Fluorotetrahydro-2H-pyran-4-yl)methanol is a reactant used to prepare GPR40 agonists and beta secretase inhibitors.
Synthesis
1150617-60-9
883442-46-4
General procedure for the synthesis of (4-fluorotetrahydro-2H-pyran-4-yl)methanol from methyl 4-fluorotetrahydro-2H-pyran-4-carboxylate: 4-fluorotetrahydro-2H-pyran-4-carboxylic acid methyl ester (840 mg, 5.18 mmol) was dissolved in tetrahydrofuran (20 mL) under nitrogen protection and cooled to 0 °C. Subsequently, lithium aluminum hydride (394 mg, 10.36 mmol) was slowly added. The reaction mixture was stirred continuously at 0 °C for 3 hours. Upon completion of the reaction, saturated aqueous ammonium chloride solution (10 mL) was carefully added to quench the reaction. The reaction mixture was filtered and the filtrate was extracted with ethyl acetate (10 mL × 2). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the intermediate (4-fluorotetrahydro-2H-pyran-4-yl)methanol (550 mg, 4.10 mmol, 80% yield) as an oil, which was used directly in the next step of the reaction. The 1H NMR (CD3OD, 400 MHz) data of the intermediate were as follows: δ 3.81-3.85 (m, 2H), 3.70-3.76 (m, 2H), 3.64 (s, 1H), 3.59 (s, 1H), 1.67-1.90 (m, 4H).
References
[1] Patent: WO2018/50684, 2018, A1. Location in patent: Page/Page column 68
(4-fluorotetrahydro-2H-pyran-4-yl)methanamine Preparation Products And Raw materials
Raw materials
Preparation Products
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