3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one

Product Name: 3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one
CAS No.: 159326-71-3
Chemical Name: 3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one
Synonyms: PYRROLO[2,1-F][1,2,4]TRIAZIN-4-OL;Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one;Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one;SKL490;Pyrrolo[2,1-f][1,2,4]triazin-4(3H);3H-pyrrolo[1,2-d][1,2,4]triazin-4-one;1H-pyrrolo[2,1-f][1,2,4]triazin-4-one;3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one;3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one;1H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one
CBNumber: CB32471373
Molecular Formula: C6H5N3O
Formula Weight: 135.12
MOL File: 159326-71-3.mol

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3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 8.16±0.20(Predicted)
Appearance: Off-white to light brown Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

AstaTech

Product number: 65664
Product name: PYRROLO[2,1-F][1,2,4]TRIAZIN-4-OL
Purity: 97%
Packaging: 1G
Price: $93
Updated: 2026/04/30

AstaTech

Product number: 65664
Product name: PYRROLO[2,1-F][1,2,4]TRIAZIN-4-OL
Purity: 97%
Packaging: 5G
Price: $280
Updated: 2026/04/30

AstaTech

Product number: 65664
Product name: PYRROLO[2,1-F][1,2,4]TRIAZIN-4-OL
Purity: 97%
Packaging: 10G
Price: $420
Updated: 2026/04/30

TRC

Product number: P998750
Product name: 3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one
Packaging: 1g
Price: $165
Updated: 2021/12/16

TRC

Product number: P998750
Product name: 3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one
Packaging: 10g
Price: $1320
Updated: 2021/12/16

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3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one Chemical Properties,Usage,Production

Uses

3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one is used in the synthesis of kinase inhibitors as the template for their creation.

Synthesis

122181-85-5

77287-34-4

159326-71-3

Step 2: Synthesis of pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one; Methyl 1-amino-1H-pyrrole-2-carboxylate (7.5 g, 53.5 mmol) was dissolved in formamide (30 mL). The reaction mixture was first heated at 170 °C for 1 h, and then warmed to 190 °C to continue the reaction for 2 h. The reaction was completed by cooling the mixture for 1 h. The reaction was then continued for 2 h. After completion of the reaction, the mixture was cooled to room temperature. The resulting solid was purified by recrystallization from ethyl acetate to afford the target product pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one as a white solid (5.0 g, 37.0 mmol, 69% yield).1H NMR (400 MHz, CDCl3) δ: 7.57 (s, 1H), 7.47 (dd, J = 2.8 Hz, 1.6 Hz (s, 1H), 7.10 (dd, J = 4.4 Hz, 1.6 Hz, 1H), 7.47 (dd, J = 4.4 Hz, 2.8 Hz, 1H).

References

[1] Patent: US2011/183983, 2011, A1. Location in patent: Page/Page column 32

3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one Suppliers

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View Lastest Price from 3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one manufacturers

Career Henan Chemical Co

Product: 3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one 159326-71-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-08

159326-71-3, 3H-Pyrrolo[2,1-f][1,2,4]triazin-4-oneRelated Search:

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SKL490

159326-71-3