3,5-Dibromo-2-chloropyrazine
- Product Name
- 3,5-Dibromo-2-chloropyrazine
- CAS No.
- 1082843-70-6
- Chemical Name
- 3,5-Dibromo-2-chloropyrazine
- Synonyms
- 2-Chloro-3,5-dibroMopyrazine;3,5-Dibromo-2-chloropyrazine;2-chlorine-3,5-dibromopyrazine;Pyrazine, 3,5-dibromo-2-chloro-;3,5-Dibromo-2-chloropyrazine ISO 9001：2015 REACH
- CBNumber
- CB32471575
- Molecular Formula
- C4HBr2ClN2
- Formula Weight
- 272.33
- MOL File
- 1082843-70-6.mol
3,5-Dibromo-2-chloropyrazine Property
- Boiling point:
- 261℃
- Density
- 2.265
- Flash point:
- 112℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -6.65±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D425230
- Product name
- 3,5-Dibromo-2-chloropyrazine
- Packaging
- 250mg
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- HCH0104175
- Product name
- 3,5-DIBROMO-2-CHLOROPYRAZINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1871.1
- Updated
- 2021/12/16
- Product number
- HCH0104175
- Product name
- 3,5-DIBROMO-2-CHLOROPYRAZINE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- OR926025
- Product name
- 3,5-Dibromo-2-chloropyrazine
- Purity
- >98%
- Packaging
- 10g
- Price
- $756
- Updated
- 2021/12/16
- Product number
- 3H32-D-4W
- Product name
- 3,5-Dibromo-2-chloropyrazine
- Purity
- 98.0%
- Packaging
- 10g
- Price
- $1210
- Updated
- 2021/12/16
3,5-Dibromo-2-chloropyrazine Chemical Properties,Usage,Production
Uses
An intermediate used for the 1) preparation of a number of salts of fused pyrazine derivative for treatment of degenerative and inflammatory diseases, 2) preparation of a number of pyridine and pyrazine derivatives as protein kinase modulators for the treatment of CDK9-mediated diseases.
Uses
3,5-Dibromo-2-chloropyrazine is an intermediate used for the 1) preparation of a number of salts of fused pyrazine derivative for treatment of degenerative and inflammatory diseases, 2) preparation of a number of pyridine and pyrazi ne derivatives as protein kinase modulators for the treatment of CDK9-mediated diseases.
Synthesis
24241-18-7
1082843-70-6
General procedure for the synthesis of 3,5-dibromo-2-chloropyrazine from 2-amino-3,5-dibromopyrazine: titanium(IV) chloride (174 g, 926 mmol) was added to a solution of 2-amino-3,5-dibromopyrazine (234 g, 932 mmol) in dichloromethane (DCM, 700 mL), followed by slow addition of tert-butyl nitrite (572 g, 5.55 mol). The reaction mixture was stirred at room temperature for 2 h and then the reaction was quenched with water (500 mL). The reaction mixture was extracted with dichloromethane (3 × 500 mL). The organic layers were combined and concentrated under reduced pressure. Purification of the residue by rapid column chromatography on silica gel (eluent: ethyl acetate/petroleum ether, 1:50 v/v) afforded 3,5-dibromo-2-chloropyrazine (90d) as a colorless oil (210 g, 83% yield). Mass spectrum (LCMS, ESI positive ion mode): calculated value C4HBr2ClN2 [M+H]+: 272.8, measured value: 272.6.
References
[1] Patent: US2014/364414, 2014, A1. Location in patent: Paragraph 0945; 0952-0953
[2] Patent: US2009/286798, 2009, A1. Location in patent: Page/Page column 26-27
[3] Patent: US2011/118269, 2011, A1. Location in patent: Page/Page column 14
[4] Patent: WO2014/1377, 2014, A1. Location in patent: Page/Page column 153; 154
3,5-Dibromo-2-chloropyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-Dibromo-2-chloropyrazine Suppliers
- Tel
- 13052276172
- Fax
- 13052276172
- product@yuyuanpharm.com
- Country
- China
- ProdList
- 493
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 10-61256048 13810278579
- Fax
- +86 10 61256049
- sales@zeroschem.com
- Country
- China
- ProdList
- 1371
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16077
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 0512-63263366 18912765016
- Fax
- 0512-6326 3366
- tongtf110@sina.com
- Country
- China
- ProdList
- 993
- Advantage
- 62
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3199
- Advantage
- 55
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- (86) 21 51969655
- Fax
- (86) 21 51969655， QQ：33109286， 263541193
- Country
- China
- ProdList
- 487
- Advantage
- 22
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 400-8592883
- Fax
- 0731-82251112
- sales@huatengsci.com
- Country
- China
- ProdList
- 5872
- Advantage
- 58
- Tel
- 025-58390181 58390186 18912901218
- Fax
- 025-58390182
- sales@fastchem.cn
- Country
- China
- ProdList
- 162
- Advantage
- 60
- Tel
- 0731-88827538 15873153880
- Fax
- 0731-88827238
- luxingbc@126.com
- Country
- China
- ProdList
- 1999
- Advantage
- 65
- Tel
- 18905173768
- Fax
- 025-83263139
- 52513593@qq.com
- Country
- China
- ProdList
- 2336
- Advantage
- 50
- Tel
- +86-021-61654350
- Fax
- +86-021-61654350
- 1245958370@qq.com
- Country
- China
- ProdList
- 2982
- Advantage
- 50
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 010-60400365-8001 15910885229
- Fax
- 010-60400361
- service@bellenchem.com
- Country
- China
- ProdList
- 4514
- Advantage
- 60
- Tel
- 0512-67213637 13952409868
- peter19zhang@163.com
- Country
- China
- ProdList
- 442
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20794
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-20432229
- Fax
- QQ2412110556
- 2412110556@qq.com
- Country
- China
- ProdList
- 6017
- Advantage
- 55
- Tel
- 0539-6362799 20）
- Fax
- 0539-6362799（To 20）
- Country
- China
- ProdList
- 9998
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 13962527677
- Fax
- -
- 1551481742@qq.com
- Country
- China
- ProdList
- 278
- Advantage
- 58
- Tel
- 0512-66565816 18651107528
- Fax
- 0512-66565816
- Country
- China
- ProdList
- 1040
- Advantage
- 58
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20557
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 0751-2815688 13927872512
- Fax
- 0751-8963795
- 3007421951@qq.com
- Country
- China
- ProdList
- 9939
- Advantage
- 58
- Tel
- 025-58867862 18751812725
- Fax
- 02558867862
- sales@ace-pharm.com
- Country
- China
- ProdList
- 1985
- Advantage
- 58
- Tel
- 0931-4190454 13893344397
- sales@kyxpharma.com
- Country
- China
- ProdList
- 3151
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 20284
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28172
- Advantage
- 58
- Tel
- 18616526224
- lianshuo@vip.126.com
- Country
- China
- ProdList
- 9607
- Advantage
- 58
- Tel
- 15901914505 15901914505;
- Fax
- 021-54389085
- 3187892335@qq.com
- Country
- China
- ProdList
- 9889
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29798
- Advantage
- 58
- Tel
- +8613580539051
- joe@yuhengpharm.com
- Country
- CHINA
- ProdList
- 21142
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
View Lastest Price from 3,5-Dibromo-2-chloropyrazine manufacturers
- Product
- 3,5-Dibromo-2-chloropyrazine 1082843-70-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
- Product
- 3,5-Dibromo-2-chloropyrazine 1082843-70-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-20