ChemicalBook > CAS DataBase List > 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester

1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester

Product Name
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
CAS No.
287193-00-4
Chemical Name
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
Synonyms
1-Boc-3-ethynylpyrrolidine;1-Boc-3-ethynylpyrrolidin...;acid, 3-ethynyl-, 1,1-dimethylethyl ester;tert-Butyl 3-ethynyl-1-pyrrolidinecarboxylate;tert-butyl 3-ethynylpyrrolidine-1-carboxylate;1,1-Dimethylethyl 3-ethynyl-1-pyrrolidinecarboxylate;1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester;3-ethynyl-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester;1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester;1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester - [P7677]
CBNumber
CB32473670
Molecular Formula
C11H17NO2
Formula Weight
195.26
MOL File
287193-00-4.mol
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1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Property

Boiling point:
249.2±29.0 °C(Predicted)
Density 
1.04±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
form 
solid
pka
-2.53±0.40(Predicted)
Appearance
White to off-white Solid
optical activity
0.9898°(C=0.1566g/100ml MEOH)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B703980
Product name
tert-butyl3-ethynylpyrrolidine-1-carboxylate
Packaging
100mg
Price
$265
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB141606
Product name
tert-Butyl 3-ethynylpyrrolidine-1-carboxylate
Packaging
500mg
Price
$430
Updated
2021/12/16
Activate Scientific
Product number
AS17323
Product name
1-Boc-3-ethynylpyrrolidine
Purity
96%
Packaging
5G
Price
$592
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB141606
Product name
tert-Butyl 3-ethynylpyrrolidine-1-carboxylate
Packaging
1g
Price
$743.75
Updated
2021/12/16
Synthonix
Product number
P7677
Product name
1-Pyrrolidinecarboxylicacid,3-ethynyl-,1,1-dimethylester
Purity
97.0%
Packaging
25g
Price
$1310
Updated
2021/12/16
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1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Chemical Properties,Usage,Production

Application

tert-butyl 3-ethynylpyrrolidine-1-carboxylate is a useful research chemical.

Synthesis

90965-06-3

59379-02-1

287193-00-4

GENERAL STEPS: 1-Boc-3-pyrrolidinecarboxaldehyde (580 mg, 2.91 mmol) was dissolved in methanol (15 mL) at room temperature, and potassium carbonate (1.00 g, 7.28 mmol) and dimethyl (1-diazido-2-oxopropyl)phosphonate (839 mg, 4.37 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 3 h. After completion of the reaction, it was filtered through a short diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with an eluent gradient of 0 to 50% ethyl acetate/hexane to give a colorless oily product. The product was allowed to stand in a refrigerator and cured to give 1-Boc-3-ynylpyrrolidine white solid (374 mg, 66% yield).

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 18, p. 8417 - 8443
[2] Patent: US2016/9720, 2016, A1. Location in patent: Paragraph 0250
[3] Patent: US2016/9711, 2016, A1. Location in patent: Paragraph 0242; 0243; 0244

1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester 287193-00-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Career Henan Chemical Co
Product
1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester 287193-00-4
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-14

287193-00-4, 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl esterRelated Search:


  • 1-Pyrrolidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
  • tert-butyl 3-ethynylpyrrolidine-1-carboxylate
  • 1-Boc-3-ethynylpyrrolidine
  • 1-Boc-3-ethynylpyrrolidin...
  • tert-Butyl 3-ethynyl-1-pyrrolidinecarboxylate
  • 3-ethynyl-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
  • 1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester
  • 1,1-Dimethylethyl 3-ethynyl-1-pyrrolidinecarboxylate
  • acid, 3-ethynyl-, 1,1-dimethylethyl ester
  • 1-Pyrrolidinecarboxylic acid, 3-ethynyl-,1,1-dimethyl ester - [P7677]
  • 287193-00-4
  • boc