ChemicalBook > CAS DataBase List > 1-(4-BOC-piperidyl)-4-iodopyrazole

1-(4-BOC-piperidyl)-4-iodopyrazole

Product Name
1-(4-BOC-piperidyl)-4-iodopyrazole
CAS No.
877399-73-0
Chemical Name
1-(4-BOC-piperidyl)-4-iodopyrazole
Synonyms
tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate;Crizotinib Impurity 16;CrizotinibIntermediate1;1-(4-BOC-piperidyl)-4-iodopyrazole;1-(4-BOC-piperazino)-4-iodopyrazole;1-(1-Boc-4-piperidinyl)-4-iodopyrazole;1-Boc-4-(4-iodo-1H-pyrazol-1-yl)piperidine;1-(1-Boc-4-piperidinyl)-4-iodopyrazole, 98%;4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate;tert-Butyl 4-(4-iodopyrazolyl)piperidinecarboxylate
CBNumber
CB32473791
Molecular Formula
C13H20IN3O2
Formula Weight
377.22
MOL File
877399-73-0.mol
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1-(4-BOC-piperidyl)-4-iodopyrazole Property

Melting point:
97 °C
Boiling point:
430.6±35.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
Solid
pka
1.08±0.19(Predicted)
Sensitive 
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H65918
Product name
1-(1-Boc-4-piperidinyl)-4-iodopyrazole, tech. 90%
Packaging
1g
Price
$159
Updated
2021/12/16
Alfa Aesar
Product number
H65918
Product name
1-(1-Boc-4-piperidinyl)-4-iodopyrazole, tech. 90%
Packaging
5g
Price
$631
Updated
2021/12/16
Alfa Aesar
Product number
H65918
Product name
1-(1-Boc-4-piperidinyl)-4-iodopyrazole, tech. 90%
Packaging
250mg
Price
$53
Updated
2021/12/16
TRC
Product number
B809635
Product name
tert-Butyl4-(4-Iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate
Packaging
25g
Price
$130
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0037519
Product name
1-(4-BOC-PIPERAZINO)-4-IODOPYRAZOLE
Purity
95.00%
Packaging
1G
Price
$848.93
Updated
2021/12/16
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1-(4-BOC-piperidyl)-4-iodopyrazole Chemical Properties,Usage,Production

Synthesis

1-(4-BOC-piperidyl)-4-iodopyrazole is prepared by the reaction of 4-Iodopyrazole and 1-Boc-4-methanesulfonyloxypiperidine. The specific synthesis steps are as follows:
To a stirred solution of 4-iodo-lH-pyrazole (8.98 g, 46.28 mmol) in DCM (160 mL) was added NaH (1.67 g, 55.53 mmol, 80percent NaH/mineral oil) portion-wise at 0 °C. The mixture was stirred at 0 °C for 1 hour, then tert-butyl 4-((methylsulfonyl)oxy)piperidine-l- carboxylate (14.22 g, 50.90 mmol) was added. The resulted mixture was stirred at 100 °C for 15 hours, then cooled to rt, quenched with H20 (30 mL) and concentrated in vacuo. The residue was diluted with H20 (150 mL), and the mixture was extracted with EtOAc (100 mL x 5). The combined organic layers were dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 5/1) to give 1-(4-BOC-piperidyl)-4-iodopyrazole as a white solid (12.25 g, 70.2percent>). MS (ESI, pos. ion) m/z: 322.0 (M-56+1).

1-(4-BOC-piperidyl)-4-iodopyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(4-BOC-piperidyl)-4-iodopyrazole manufacturers

Henan Fengda Chemical Co., Ltd
Product
1-PIPERIDINECARBOXYLIC ACID 4-(4-IODO-1H-PYRAZOL-1YL)-,1-1-DIMETHYLETHYLESTER 877399-73-0
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-31
Henan Aochuang Chemical Co.,Ltd.
Product
1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester 877399-73-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester 877399-73-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

877399-73-0, 1-(4-BOC-piperidyl)-4-iodopyrazoleRelated Search:

Pyrazole Piperidinylpiperidine

  • 1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester
  • Crizotinib Impurity 16
  • tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate
  • 1-(4-BOC-piperazino)-4-iodopyrazole
  • 1-(4-BOC-piperidyl)-4-iodopyrazole
  • 1-Boc-4-(4-iodo-1H-pyrazol-1-yl)piperidine
  • 4-(4-Iodo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester
  • tert-Butyl 4-(4-iodopyrazolyl)piperidinecarboxylate
  • 1-Piperidinecarboxylic acid, 4-(4-iodo-1H-pyrazol-1-yl)-
  • 1-(1-Boc-4-piperidinyl)-4-iodopyrazole
  • tert-butyl 4-(4-iodopyrazol-1-yl)piperidine-1-carboxylate
  • 1-(1-Boc-4-piperidinyl)-4-iodopyrazole, 98%
  • CrizotinibIntermediate1
  • 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate
  • 877399-73-0
  • 877399-70-3