ethyl pyrrolidine-3-carboxylate

Product Name: ethyl pyrrolidine-3-carboxylate
CAS No.: 72925-15-6
Chemical Name: ethyl pyrrolidine-3-carboxylate
Synonyms: Ethyl 3-pyrrolidinecarboxylate;ethyl pyrrolidine-3-carboxylate;3-Pyrrolidinecarboxylic acid, ethyl ester
CBNumber: CB32476055
Molecular Formula: C7H13NO2
Formula Weight: 143.18
MOL File: 72925-15-6.mol

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ethyl pyrrolidine-3-carboxylate Property

Boiling point:: 191℃
Density: 1.031
refractive index: 1.4531
Flash point:: 70℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.49±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0386342
Product name: ETHYL PYRROLIDINE-3-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $504.36
Updated: 2021/12/16

Crysdot

Product number: CD21003569
Product name: Ethylpyrrolidine-3-carboxylate
Purity: 97%
Packaging: 5g
Price: $759
Updated: 2021/12/16

Chemenu

Product number: CM128855
Product name: ethylpyrrolidine-3-carboxylate
Purity: 95%
Packaging: 5g
Price: $982
Updated: 2021/12/16

Alichem

Product number: 72925156
Product name: Ethylpyrrolidine-3-carboxylate
Packaging: 5g
Price: $1155
Updated: 2021/12/16

Chemenu

Product number: CM128855
Product name: ethylpyrrolidine-3-carboxylate
Purity: 95%
Packaging: 1g
Price: $239
Updated: 2021/12/16

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ethyl pyrrolidine-3-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 3-pyrrolidinecarboxylate is used to prepare inhibitors of γ-aminobutyric acid transporter 1.

Synthesis

5747-92-2

72925-15-6

General procedure for the synthesis of ethyl 3-pyrrolidinecarboxylate from ethyl 1-benzylpyrrolidine-3-carboxylate: ethyl 1-benzylpyrrolidine-3-carboxylate (10.00 g, 42.9 mmol) was dissolved in ethanol (200 mL) and 10% Pd/C catalyst (2.0 g) was added. The reaction was hydrogenated for 6 hours at room temperature under 60 psi hydrogen pressure. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filter cake was washed with dichloromethane (CH2Cl2). The filtrate and washings were combined and concentrated under reduced pressure to give the crude product ethyl 3-pyrrolidinecarboxylate (7.12 g, 100% yield). The product was characterized by 1H NMR (CDCl3): δ 4.16 (q, 2H), 3.02-3.17 (m, 3H), 2.82-2.94 (m, 2H), 1.91-2.07 (m, 2H), 1.26 (t, 3H).LC-MS (APCI+) analysis showed the molecular ion peak m/z 144 (100%, [MH]+).

References

[1] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 89; 90; 129; 130
[2] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 117; 118; 157; 158
[3] Patent: US2010/120793, 2010, A1. Location in patent: Page/Page column 36
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 2, p. 233 - 241
[5] Patent: US5686463, 1997, A

ethyl pyrrolidine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl pyrrolidine-3-carboxylate Suppliers

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View Lastest Price from ethyl pyrrolidine-3-carboxylate manufacturers

Career Henan Chemical Co

Product: ethyl pyrrolidine-3-carboxylate 72925-15-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-08

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72925-15-6