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Tyr-α-CGRP (human)

Product Name
Tyr-α-CGRP (human)
CAS No.
124756-98-5
Chemical Name
Tyr-α-CGRP (human)
Synonyms
Tyr-α-CGRP (human);Tyr-a-CGRP (huMan);Tyr-α-CGRP (human);Tyr-α-CGRP (huMan) Tyr-CGRP I (huMan);Tyr-α-CGRP (huMan) Tyr-CGRP I (huMan);Tyr-α-CGRP (human) (trifluoroacetate salt);Tyr-alpha-CGRP (human) trifluoroacetate salt;α-Calcitonin gene-related peptide (human), N-L-tyrosyl- (9CI);H-Tyr-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2
CBNumber
CB32477229
Molecular Formula
C174H277F3N52O53S2
Formula Weight
4066.5029896
MOL File
124756-98-5.mol
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Tyr-α-CGRP (human) Property

storage temp. 
Store at -20°C
solubility 
Water: 1 mg/ml
form 
A lyophilized powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24724
Product name
Tyr-α-CGRP (human) (trifluoroacetate salt)
Purity
≥95%
Packaging
1 mg
Price
$305
Updated
2024/03/01
Cayman Chemical
Product number
24724
Product name
Tyr-α-CGRP (human) (trifluoroacetate salt)
Purity
≥95%
Packaging
500μg
Price
$211
Updated
2023/01/06
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Tyr-α-CGRP (human) Chemical Properties,Usage,Production

Description

Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide (α-CGRP; ).1 It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively).2 Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM).1 It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).3

References

1. Poyner, D.R., Andrew, D.P., Brown, D., et al. Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes Br. J. Pharmacol. 105(2),441-447(1992).
2. Hay, D.L., Christopoulos, G., Christopoulos, A., et al. Pharmacological discrimination of calcitonin receptor: Receptor activity-modifying protein complexes Mol. Pharmacol. 67(5),1655-1665(2005).
3. Dennis, T., Fournier, A., St. Pierre, S., et al. Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity J. Pharmacol. Exp. Ther. 251(2),718-725(1989).

Tyr-α-CGRP (human) Preparation Products And Raw materials

Raw materials

Preparation Products

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Tyr-α-CGRP (human) Suppliers

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GL Biochem (Shanghai) Ltd
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124756-98-5, Tyr-α-CGRP (human)Related Search:

TYR-CORTICOTROPIN RELEASING FACTOR HUMAN, RAT TYR-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2 TYR-AMYLOID P COMPONENT (27-38) AMIDE

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