ChemicalBook > CAS DataBase List > (3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone

(3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone

Product Name
(3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone
CAS No.
869490-23-3
Chemical Name
(3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone
Synonyms
PF-734200;PF-00734200;Gosogliptin;(3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone;Methanone, (3,3-difluoro-1-pyrrolidinyl)[(2S,4S)-4-[4-(2-pyrimidinyl)-1-piperazinyl]-2-pyrrolidinyl]-
CBNumber
CB32484726
Molecular Formula
C17H24F2N6O
Formula Weight
366.41
MOL File
869490-23-3.mol
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(3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone Property

Boiling point:
562.3±60.0 °C(Predicted)
Density 
1.36
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
pka
8.95±0.10(Predicted)
color 
White to yellow
InChI
InChI=1S/C17H24F2N6O/c18-17(19)2-5-25(12-17)15(26)14-10-13(11-22-14)23-6-8-24(9-7-23)16-20-3-1-4-21-16/h1,3-4,13-14,22H,2,5-12H2/t13-,14-/m0/s1
InChIKey
QWEWGXUTRTXFRF-KBPBESRZSA-N
SMILES
C(N1CCC(F)(F)C1)([C@@H]1C[C@H](N2CCN(C3=NC=CC=N3)CC2)CN1)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6619
Product name
Gosogliptin
Purity
99.27%
Packaging
1mg
Price
$360
Updated
2021/12/16
ChemScene
Product number
CS-6619
Product name
Gosogliptin
Purity
99.27%
Packaging
5mg
Price
$720
Updated
2021/12/16
ChemScene
Product number
CS-6619
Product name
Gosogliptin
Purity
99.27%
Packaging
10mg
Price
$1224
Updated
2021/12/16
ChemScene
Product number
CS-6619
Product name
Gosogliptin
Purity
99.27%
Packaging
20mg
Price
$2160
Updated
2021/12/16
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(3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone Chemical Properties,Usage,Production

Uses

Gosogliptin is used as a treatment for type 2 diabetes.

Definition

ChEBI: Gosogliptin is an amino acid amide.

in vivo

The objectives of the present study are to characterize the metabolism, pharmacokinetics, and excretion of [14C] Gosogliptin in Sprague-Dawley (SD) rats, beagle dogs, and humans. A single dose of [14C] Gosogliptin is administered orally to intact SD rats (5 mg/kg), beagle dogs (5 mg/kg), and humans (20 mg). After a single oral dose of [14C] Gosogliptin to SD rats, an overall mean of 97.1% of the administered radioactivity is recovered in the urine, feces, and cage wash over a period of 168 h postdose. The mean cumulative dose recovered in feces is 66.0%. The mean cumulative excretion in the urine is 30.8%. Approximately 95% of the excreted radioactivity recovery occurred in the first 48 h. Mean total recoveries of dosed radioactivity from bile duct-cannulated rats are 29.5% in urine and 62.0% in bile. No gender-related differences are observed in the excretion pattern of radioactivity[2].

IC 50

DPP-4

(3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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(3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone Suppliers

China 31 United States 6 USA 1 Global 38
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869490-23-3, (3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanoneRelated Search:


  • (3,3-Difluoropyrrolidin-1-yl)[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone
  • Gosogliptin
  • PF-00734200
  • PF-734200
  • Methanone, (3,3-difluoro-1-pyrrolidinyl)[(2S,4S)-4-[4-(2-pyrimidinyl)-1-piperazinyl]-2-pyrrolidinyl]-
  • 869490-23-3
  • C17H24F2N6O