Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate

Product Name: Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate
CAS No.: 916325-83-2
Chemical Name: Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate
Synonyms: Methyl 1H-pyrazolo[3,4-b]...;1H-pyrazolo[3,4-b]pyridine-3-carboxylate;Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate;Methyl 2H-pyrazolo[3,4-b]pyridine-3-carboxylate;pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester;2H-pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester;1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid, Methyl ester
CBNumber: CB32485596
Molecular Formula: C8H7N3O2
Formula Weight: 177.16
MOL File: 916325-83-2.mol

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Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate Property

Boiling point:: 362.9±22.0 °C(Predicted)
Density: 1.403±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.85±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M643400
Product name: methyl1H-pyrazolo[3,4-b]pyridine-3-carboxylate
Packaging: 1g
Price: $350
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-01
Product name: Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate
Purity: 98%
Packaging: 1g
Price: $375
Updated: 2021/12/16

Matrix Scientific

Product number: 068504
Product name: 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl ester
Purity: >95%
Packaging: 1g
Price: $385
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1052138
Product name: METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $454.4
Updated: 2021/12/16

AK Scientific

Product number: 5431AC
Product name: Methyl2H-pyrazolo[3,4-b]pyridine-3-carboxylate
Packaging: 1g
Price: $569
Updated: 2021/12/16

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Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate Chemical Properties,Usage,Production

Synthesis

67-56-1

116855-08-4

916325-83-2

Step 5: To a solution of 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (V) (0.39 g, 2.4 mmol) in anhydrous methanol (10 mL) was slowly added concentrated sulfuric acid (4 drops) and the reaction was refluxed under nitrogen protection for 6 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and the solvent was subsequently removed by evaporation under reduced pressure. The residue was partitioned between dichloromethane and saturated sodium bicarbonate solution. The organic layer was separated, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast silica gel column chromatography (elution gradient: 100% dichloromethane → 100:3 dichloromethane:methanol) to afford methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate (VI) as a white solid (382 mg, 2.16 mmol, 90% yield).1H NMR (CDCl3) δ ppm: 4.08 (s, 3H) 7.38 (m, 1H), 8.63 (dd, J = 8.10, 1.51 Hz, 1H), 8.72 (dd, J = 4.62, 1.41 Hz, 1H); ESIMS m/z: 178.2 ([M + H]+).

References

[1] Patent: WO2011/84486, 2011, A1. Location in patent: Page/Page column 106; 112
[2] Patent: US2013/296302, 2013, A1. Location in patent: Paragraph 0497
[3] Patent: US2016/68550, 2016, A1. Location in patent: Paragraph 1059
[4] Patent: WO2016/40193, 2016, A1. Location in patent: Paragraph 0706
[5] Patent: US2006/47126, 2006, A1. Location in patent: Page/Page column 31

Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate Suppliers

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916325-83-2