3,4-Dihydro Naratriptan (Naratriptan Impurity B)

Product Name: 3,4-Dihydro Naratriptan (Naratriptan Impurity B)
CAS No.: 121679-20-7
Chemical Name: 3,4-Dihydro Naratriptan (Naratriptan Impurity B)
Synonyms: Naratriptan Impurity 4;Naratriptan IMpurity B;3,4-Dihydro Naratriptan;3,4-Dihydro Naratriptan (Naratriptan Impurity B);3,4-Didehydro Naratriptan (Naratriptan Impurity B);N-Methyl-3-(1,2,3,6-tetrahydro-1-Methyl-4-pyridinyl)-1H-indole-5-ethanesulfonaMide;N-methyl-2-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]ethanesulfonamide;1H-Indole-5-ethanesulfonamide, N-methyl-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-;N-Methyl-2-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl) ethane sulfonamide
CBNumber: CB32486669
Molecular Formula: C17H23N3O2S
Formula Weight: 333.45
MOL File: 121679-20-7.mol

More

Less

3,4-Dihydro Naratriptan (Naratriptan Impurity B) Property

Melting point:: >187°C (dec.)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 17890
Product name: 3,4-dihydro Naratriptan
Purity: ≥95%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 17890
Product name: 3,4-dihydro Naratriptan
Purity: ≥95%
Packaging: 1mg
Price: $43
Updated: 2023/01/06

Cayman Chemical

Product number: 17890
Product name: 3,4-dihydro Naratriptan
Purity: ≥95%
Packaging: 10mg
Price: $224
Updated: 2024/03/01

Cayman Chemical

Product number: 17890
Product name: 3,4-dihydro Naratriptan
Purity: ≥95%
Packaging: 25mg
Price: $528
Updated: 2023/01/06

TRC

Product number: D449205
Product name: 3,4-DihydroNaratriptan(NaratriptanImpurityB)
Packaging: 100mg
Price: $640
Updated: 2021/12/16

More

Less

3,4-Dihydro Naratriptan (Naratriptan Impurity B) Chemical Properties,Usage,Production

Uses

Naratriptan related compound B. Naratriptan impurity B.

Biological Activity

pki: 8.9 of naratriptan for human 5-ht1b3,4-dihydro naratriptan is a selective serotonin 5-ht1b agonist.5-ht1b receptors are widely distributed throughout the cns with the highest concentrations found in the basal ganglia, frontal cortex, striatum, and the hippocampus. the function of the 5-ht1b receptor differs depending upon its location.

in vitro

3,4-dihydro naratriptan is an impurity formed during the preparation of naratriptan. naratriptan had high affinity for human recombinant 5ht1b and 5ht1d receptors and could cause contractions of dog isolated basilar and middle cerebral artery. naratriptan also caused small contractions of human isolated coronary arteries [1].

in vivo

in anaesthetized dogs, naratriptan caused selective vasoconstriction of the carotid arterial bed and, in anaesthetized rats, naratriptan selectively inhibited neurogenic plasma protein extravasation in the dura. in various antinociceptive tests, naratriptan had no effect even at high doses. in conscious rats and dogs, naratriptan had high oral bioavailability [1].

References

[1] connor he, feniuk w, beattie dt, north pc, oxford aw, saynor da, humphrey pp. naratriptan: biological profile in animal models relevant to migraine. cephalalgia. 1997 may;17(3):145-52.
[2] dulli da. naratriptan: an alternative for migraine. ann pharmacother. 1999 jun;33(6):704-11.

3,4-Dihydro Naratriptan (Naratriptan Impurity B) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3,4-Dihydro Naratriptan (Naratriptan Impurity B) Suppliers

Canada 1 CHINA 27 India 5 United States 2 Global 35

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@163.com
Country: China
ProdList: 283
Advantage: 58

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Hefei fuya biotechnology co. LTD

Tel: 18096409024
Email: sales02@foreversyn.com
Country: China
ProdList: 1961
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

121679-20-7, 3,4-Dihydro Naratriptan (Naratriptan Impurity B)Related Search:

3,4-Dihydro Naratriptan (Naratriptan Impurity B)

3,4-Dihydro Naratriptan

Naratriptan IMpurity B

N-Methyl-2-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl) ethane sulfonamide

N-Methyl-3-(1,2,3,6-tetrahydro-1-Methyl-4-pyridinyl)-1H-indole-5-ethanesulfonaMide

Naratriptan Impurity 4

1H-Indole-5-ethanesulfonamide, N-methyl-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-

N-methyl-2-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]ethanesulfonamide

3,4-Didehydro Naratriptan (Naratriptan Impurity B)

121679-20-7

Indole Derivatives

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds