N-(2-Aminophenyl)-N'-phenylheptanediamide

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N-(2-Aminophenyl)-N'-phenylheptanediamide

Product Name: N-(2-Aminophenyl)-N'-phenylheptanediamide
CAS No.: 537034-15-4
Chemical Name: N-(2-Aminophenyl)-N'-phenylheptanediamide
Synonyms: NKL 22;HDACi-4b;MDK-4154;NKL22, >98%;NKL 22, >98%;HDAC inhibitor IV;Histone Deacetylase Inhibitor IV;N-(2-Aminophenyl)-N'-phenylheptanediamide;N1-(2-AMinophenyl)-N7-phenylheptanediaMide;Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-
CBNumber: CB32486755
Molecular Formula: C19H23N3O2
Formula Weight: 325.4
MOL File: 537034-15-4.mol

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N-(2-Aminophenyl)-N'-phenylheptanediamide Property

Melting point:: 159-161°C
Boiling point:: 627.9±40.0 °C(Predicted)
Density: 1.212±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO, Methanol
form: Beige solid
pka: 14?+-.0.70(Predicted)
color: Off-White to Pale Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 382170
Product name: Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem
Packaging: 10mg
Price: $335
Updated: 2023/01/07

Cayman Chemical

Product number: 22942
Product name: PAOA
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 22942
Product name: PAOA
Purity: ≥95%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 22942
Product name: PAOA
Purity: ≥95%
Packaging: 25mg
Price: $412
Updated: 2024/03/01

TRC

Product number: A625980
Product name: N-(2-Aminophenyl)-N’-phenylheptanediamide
Packaging: 5mg
Price: $120
Updated: 2021/12/16

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N-(2-Aminophenyl)-N'-phenylheptanediamide Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich’s ataxia) cells due to hypoacetylation of histones H3 and H4.

General Description

A cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich′s ataxia) cells (~3-fold increase of FXN mRNA at 5 μM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 μM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No. 647925 and 647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on FXN transcription.

Biochem/physiol Actions

Cell permeable: yes

N-(2-Aminophenyl)-N'-phenylheptanediamide Preparation Products And Raw materials

Raw materials

Preparation Products

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537034-15-4, N-(2-Aminophenyl)-N'-phenylheptanediamideRelated Search:

N-(2-Aminophenyl)-N'-phenylheptanediamide

N1-(2-AMinophenyl)-N7-phenylheptanediaMide

NKL 22

HDAC inhibitor IV

Histone Deacetylase Inhibitor IV

HDACi-4b

HISTONE DEACETYLASE INHIBITOR IV;NKL22;NKL-22;NKL 22

NKL 22, >98%

NKL22, >98%

MDK-4154

Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem

Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-

Huntington's,abnormalities,histone,NKL 22,Histone deacetylases,transcriptional,HDAC,NKL-22,Inhibitor,deacetylases,phenotype,inhibit,NKL22

537034-15-4

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