2-CHLORO-3-METHYLBENZAL DEHYDE
- Product Name
- 2-CHLORO-3-METHYLBENZAL DEHYDE
- CAS No.
- 61563-28-8
- Chemical Name
- 2-CHLORO-3-METHYLBENZAL DEHYDE
- Synonyms
- 2-CHLORO-3-METHYLBENZAL DEHYDE;Benzaldehyde, 2-chloro-3-methyl-;2-Chloro-3-methylbenzaldehyde 95+%
- CBNumber
- CB32487646
- Molecular Formula
- C8H7ClO
- Formula Weight
- 154.59
- MOL File
- 61563-28-8.mol
2-CHLORO-3-METHYLBENZAL DEHYDE Property
- Boiling point:
- 228.4±20.0 °C(Predicted)
- Density
- 1.195±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2912290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2715-5-07
- Product name
- 2-Chloro-3-methylbenzaldehyde
- Purity
- 95.0%
- Packaging
- 100mg
- Price
- $106
- Updated
- 2021/12/16
- Product number
- 2715-5-07
- Product name
- 2-Chloro-3-methylbenzaldehyde
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- X2718
- Product name
- 2-Chloro-3-methylbenzaldehyde
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 2715-5-07
- Product name
- 2-Chloro-3-methylbenzaldehyde
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $423
- Updated
- 2021/12/16
- Product number
- X2718
- Product name
- 2-Chloro-3-methylbenzaldehyde
- Packaging
- 1g
- Price
- $424
- Updated
- 2021/12/16
2-CHLORO-3-METHYLBENZAL DEHYDE Chemical Properties,Usage,Production
Synthesis
61563-27-7
61563-28-8
The general procedure for the synthesis of 2-chloro-3-methylbenzaldehyde from (2-chloro-3-methylphenyl)methanol is as follows: 1. dichloromethane (30 mL) was cooled to -78 °C under nitrogen protection, and a solution of DCM (10 mL) with oxalyl chloride (1.34 mL, 15.2 mmol, 1.2 eq.) and DMSO (2.2 mL, 31.7 mmol, 2.5 eq.) was added sequentially. 2. After stirring the reaction mixture for 15 minutes, a solution of 2-chloro-3-methylbenzyl alcohol (2 g, 12.7 mmol, 1 eq.) in DCM (12 mL) was added slowly and dropwise. 3. After continuing the reaction for 30 minutes, triethylamine (9.03 mL, 63.5 mmol, 5 eq.) was added in a single addition and the reaction mixture was slowly warmed to room temperature over a period of 1 hour. 4. After completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate (50 mL) and the aqueous layer was extracted with DCM (2 x 50 mL). 5. The organic phases were combined, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to give 2-chloro-3-methylbenzaldehyde as a yellow oil (1.8 g, 91.4% yield). 6. The product was characterized by 1H NMR (300 MHz, CDCl3): δ= 10.53 (1H, s, CHO), 7.81-7.74 (1H, m, ArH), 7.53-7.46 (1H, m, ArH), 7.34-7.23 (1H, m, ArH), 2.46 (3H, s, CH3).
References
[1] Patent: WO2004/52858, 2004, A2. Location in patent: Page 133
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 3, p. 892 - 913
[3] Patent: WO2017/156177, 2017, A1. Location in patent: Paragraph 00276
[4] Patent: WO2017/156181, 2017, A1. Location in patent: Paragraph 00250
[5] Patent: WO2017/156165, 2017, A1. Location in patent: Paragraph 00316; 00319; 00320
2-CHLORO-3-METHYLBENZAL DEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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