2-(pyridin-4-ylmethylamino)nicotinic acid

Product Name: 2-(pyridin-4-ylmethylamino)nicotinic acid
CAS No.: 854382-06-2
Chemical Name: 2-(pyridin-4-ylmethylamino)nicotinic acid
Synonyms: Nicotinamide Impurity 274;2-(pyridin-4-ylmethylamino)nicotinic acid;2-(4-pyridylmethylamino)pyridine-3-carboxylic acid;2-[(4-Pyridinylmethyl)amino]-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 2-[(4-pyridinylmethyl)amino]-;2-((pyridin-4-ylmethyl)amino)nicotinic acid hydrochloride
CBNumber: CB32489756
Molecular Formula: C12H11N3O2
Formula Weight: 229.23
MOL File: 854382-06-2.mol

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2-(pyridin-4-ylmethylamino)nicotinic acid Property

Boiling point:: 461.7±40.0 °C(Predicted)
Density: 1.359
storage temp.: 2-8°C
pka: 1.71±0.36(Predicted)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P854260
Product name: 2-((Pyridin-4-ylmethyl)amino)nicotinicAcid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 053464
Product name: 2-[(4-Pyridinylmethyl)amino]nicotinic acid
Packaging: 500mg
Price: $237
Updated: 2021/12/16

AK Scientific

Product number: Z5193
Product name: 2-((Pyridin-4-ylmethyl)amino)nicotinicacid
Packaging: 1g
Price: $359
Updated: 2021/12/16

Matrix Scientific

Product number: 053464
Product name: 2-[(4-Pyridinylmethyl)amino]nicotinic acid
Packaging: 2.500g
Price: $720
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0089294
Product name: 2-[(4-PYRIDINYLMETHYL)AMINO]NICOTINIC ACID
Purity: 95.00%
Packaging: 500MG
Price: $837.38
Updated: 2021/12/16

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2-(pyridin-4-ylmethylamino)nicotinic acid Chemical Properties,Usage,Production

Synthesis

3731-53-1

2942-59-8

854382-06-2

General procedure for the synthesis of 2-[(4-pyridinylmethyl)amino]nicotinic acid from 4-methylaminopyridine and 2-chloronicotinic acid: 2-chloronicotinic acid (25.3 mmol), a catalytic amount of copper oxide, and potassium carbonate (25.3 mmol) were added to a 100 mL round-bottomed flask, which was stirred at room temperature for 20 minutes. Subsequently, 4-dimethylaminopyridine (50.6 mmol) was added and the reaction mixture was heated to 110°C and maintained for 2 hours. After completion of the reaction, ethyl acetate was added, stirred to room temperature and then filtered. The filter cake was first washed twice with ethyl acetate and then dissolved in 20 mL of water. The pH of the solution was adjusted to 5-6 with 4N hydrochloric acid, left to stand and then filtered. The resulting filter cake was dried to obtain the crude product. The product was further purified by hot pulping with ethanol, and 5.16 g of off-white solid was obtained after filtration in 89% yield.

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2930 - 2943
[2] Patent: CN106565599, 2017, A. Location in patent: Paragraph 0082-0086
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 21, p. 6003 - 6008

2-(pyridin-4-ylmethylamino)nicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(pyridin-4-ylmethylamino)nicotinic acid Suppliers

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View Lastest Price from 2-(pyridin-4-ylmethylamino)nicotinic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-(pyridin-4-ylmethylamino)nicotinic acid 854382-06-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

854382-06-2, 2-(pyridin-4-ylmethylamino)nicotinic acidRelated Search:

2-((pyridin-4-ylmethyl)amino)nicotinic acid hydrochloride

2-(pyridin-4-ylmethylamino)nicotinic acid

2-[(4-Pyridinylmethyl)amino]-3-pyridinecarboxylic acid

2-(4-pyridylmethylamino)pyridine-3-carboxylic acid

3-Pyridinecarboxylic acid, 2-[(4-pyridinylmethyl)amino]-

Nicotinamide Impurity 274

854382-06-2