ChemicalBook > CAS DataBase List > 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

Product Name
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
CAS No.
97657-92-6
Chemical Name
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
Synonyms
CS-784;DiMebone HCl;Dimebon 2HCl;Latrepirdine 2HCl;DiMebone dihydrochloride;Latrepirdine 2HCl ，S1245;DiMeboline dihydrochloride;Latrepirdine dihydrochloride;Latrepirdine (Dimebolin) HCl;Dimebone dihydrochloride hydrate
CBNumber
CB32489958
Molecular Formula
C21H25N3.2ClH
Formula Weight
392.371
MOL File
97657-92-6.mol
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2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Property

Melting point:
220-222 °C
storage temp. 
Desiccate at RT
solubility 
H2O: ≥10mg/mL
form 
powder
color 
white to off-white
Water Solubility 
H2O: ≥10mg/mL
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/38
Safety Statements 
26-36/39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D6196
Product name
Dimebon dihydrochloride hydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$152
Updated
2025/07/31
Sigma-Aldrich
Product number
D6196
Product name
Dimebon dihydrochloride hydrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$597
Updated
2025/07/31
Cayman Chemical
Product number
10011349
Product name
Dimebolin (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$23
Updated
2024/03/01
Cayman Chemical
Product number
10011349
Product name
Dimebolin (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
10011349
Product name
Dimebolin (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$155
Updated
2024/03/01
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2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Chemical Properties,Usage,Production

Uses

Latrepirdine is an antihistamine drug used initially in Russia. Recently research have explore the potential of Latrepirdine to demonstrate activities against neurodegenerative conditions.

Biological Activity

Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT 6 and 5-HT 7 ), α -adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β -amyloid fragment.

in vivo

Latrepirdine treatment of TgCRND8 transgenic mice is associated with improved learning behavior and with a reduction in accumulation of Aβ42 and α-synuclein. Male, 90-day-old TgCRND8 mice or their wild-type littermates (nTg) receive 31 consecutive once daily i.p. injections of either 3.5 mg/kg Latrepirdine or 0.9% saline (vehicle). At the culmination of treatment, mice are tested for cued and contextual fear conditioning using a paradigm that has been widely accepted for evaluating learning and memory deficits in APP transgenic mice. A significant increase in cued memory only among Latrepirdine-versus vehicle-treated TgCRND8 mice (p=0.01) is observed. A weak, non-significant trend toward an improvement in contextual memory among Latrepirdine-versus vehicle-treated mice (p=0.099) is also observed[1].

2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride Suppliers

China 105 India 1 United Kingdom 2 United States 18 Global 126
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Taizhou Yikang Chemical Co., Ltd.
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View Lastest Price from 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride 97657-92-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Career Henan Chemical Co
Product
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride 97657-92-6
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

97657-92-6, 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochlorideRelated Search:

2,2-DIMETHYLTETRAHYDROFURAN Tetrahydropyran 5,6,7,8-TETRAHYDROISOQUINOLINE Tetrahydrofurfuryl alcohol Apalutamide Bafetinib GW 4064 Bicalutamide GDC-0068 Flutamide

  • CS-784
  • Latrepirdine 2HCl
  • 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
  • Dimebon 2HCl
  • 2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole hydrochloride
  • 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indoledihydrochloride
  • DiMebone HCl
  • DiMeboline dihydrochloride
  • DiMebone dihydrochloride
  • Latrepirdine dihydrochloride
  • 2,8-dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride
  • 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate
  • Dimebolin dihydrochloride hydrate
  • Dimeboline dihydrochloride hydrate
  • Dimebone dihydrochloride hydrate
  • 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole,dihydrochloride
  • 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride ISO 9001：2015 REACH
  • Latrepirdine (Dimebolin) HCl
  • Dimebolin dihydrochloride|||Latrepirdine|||Latrepirdine 2HCl|||Dimebolin
  • Latrepirdine dihydrochloride, 10 mM in DMSO
  • 2,8-Dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride , Latrepirdine 2HCl
  • 2,3,4,5-Tetrahydro-2,8-dimethy1-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
  • Latrepirdine 2HCl ，S1245
  • 97657-92-6
  • C21H25N32HCl
  • C21H25N32ClH
  • C21H27Cl2N3
  • Inhibitors