methyl 6-(bromomethyl)nicotinate
- Product Name
- methyl 6-(bromomethyl)nicotinate
- CAS No.
- 131803-48-0
- Chemical Name
- methyl 6-(bromomethyl)nicotinate
- Synonyms
- methyl 6-(bromomethyl)nicotinate;6-Bromomethyl-nicotinic acid methyl ester;Methyl 6-bromomethylpyridin-3-carboxylate;3-Pyridinecarboxylic acid, 6-(broMoMethyl)-;Methyl 2-(bromomethyl)pyridine-5-carboxylate;6-Bromomethylpyridin-3-carboxylic acid methyl ester;6-(bromomethyl)-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 6-(bromomethyl)-, methyl ester
- CBNumber
- CB32490291
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 131803-48-0.mol
methyl 6-(bromomethyl)nicotinate Property
- Boiling point:
- 284.9±30.0℃ (760 Torr)
- Density
- 1.533±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 126.1±24.6℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.40±0.22(Predicted)
- form
- solid
- color
- OFF WHITE
- InChI
- InChI=1S/C8H8BrNO2/c1-12-8(11)6-2-3-7(4-9)10-5-6/h2-3,5H,4H2,1H3
- InChIKey
- IRQSKJQDKUAART-UHFFFAOYSA-N
- SMILES
- C1=NC(CBr)=CC=C1C(OC)=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M294403
- Product name
- Methyl6-(Bromomethyl)nicotinate
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- OR346134
- Product name
- Methyl6-(bromomethyl)nicotinate
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 4H58-9-1L
- Product name
- 6-Bromomethylnicotinic acid methyl ester
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
- Product number
- 5893AA
- Product name
- Methyl6-(bromomethyl)nicotinate
- Packaging
- 1g
- Price
- $271
- Updated
- 2021/12/16
- Product number
- 058783
- Product name
- 6-Bromomethyl-nicotinic acid methyl ester
- Purity
- 90+%
- Packaging
- 1g
- Price
- $322
- Updated
- 2021/12/16
methyl 6-(bromomethyl)nicotinate Chemical Properties,Usage,Production
Uses
methyl 6-(bromomethyl)nicotinate is an organic reagent mainly used in chemical and scientific laboratory research.
Synthesis
methyl 6-(bromomethyl)nicotinate is synthesised using methyl 6-methylnicotinate as a raw material by chemical reaction. The specific synthesis steps are as follows:
0.471 g (1.0 equivalent) of N-bromosuccinimide and 64 mg (0.1 equivalent) of benzoyl peroxide are added to a solution of 0.4 g of the product obtained in the preceding Stage 1 in 15 ml of carbon tetrachloride. The solution is brought to reflux for 6 hours, then filtered and evaporated under reduced pressure. The residue is purified by chromatography on silica gel (dichloromethane/ethyl acetate: 95/5) to produce 0.262 g of the expected product. [ Yield: 43percent MS: MH+ 231].
References
[1] Organic and Biomolecular Chemistry, 2009, vol. 7, # 24, p. 5074 - 5077
[2] Journal of the American Chemical Society, 2002, vol. 124, # 21, p. 6009 - 6019
[3] Tetrahedron Asymmetry, 1990, vol. 1, # 9, p. 571 - 574
[4] Patent: US2004/72871, 2004, A1. Location in patent: Page/Page column 19-20
[5] Journal of Medicinal Chemistry, 2002, vol. 45, # 23, p. 5005 - 5022
methyl 6-(bromomethyl)nicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from methyl 6-(bromomethyl)nicotinate manufacturers
- Product
- methyl 6-(bromomethyl)nicotinate 131803-48-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25