4-(4-Bromophenethyl)morpholine
- Product Name
- 4-(4-Bromophenethyl)morpholine
- CAS No.
- 736991-39-2
- Chemical Name
- 4-(4-Bromophenethyl)morpholine
- Synonyms
- 4-(4-Bromophenethyl)morpholine;4-[2-(4-bromophenyl)ethyl]morpholine;Morpholine, 4-[2-(4-bromophenyl)ethyl]-
- CBNumber
- CB32490514
- Molecular Formula
- C12H16BrNO
- Formula Weight
- 270.17
- MOL File
- 736991-39-2.mol
4-(4-Bromophenethyl)morpholine Property
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B678665
- Product name
- 4-(4-Bromophenethyl)morpholine
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 150294
- Product name
- 4-(4-Bromophenethyl)morpholine
- Purity
- 95%
- Packaging
- 1g
- Price
- $289
- Updated
- 2021/12/16
- Product number
- HCH0365211
- Product name
- 4-(4-BROMOPHENETHYL)MORPHOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $307.65
- Updated
- 2021/12/16
- Product number
- Y5537
- Product name
- 4-(4-Bromophenethyl)morpholine
- Packaging
- 250mg
- Price
- $111
- Updated
- 2021/12/16
- Product number
- 150294
- Product name
- 4-(4-Bromophenethyl)morpholine
- Purity
- 95%
- Packaging
- 5g
- Price
- $896
- Updated
- 2021/12/16
4-(4-Bromophenethyl)morpholine Chemical Properties,Usage,Production
Uses
4-(4-Bromophenethyl)morpholine is used as a reactant in the preparation of methyllysine reader protein L3MBTL3 inhibitors.
Synthesis
349428-85-9
736991-39-2
The general procedure for the synthesis of 4-(4-bromophenethyl)morpholine from 2-(4-bromophenyl)-1-morpholine ethanone was as follows: lithium aluminum hydride (3.35 g, 88.16 mmol, 2.00 eq.) was suspended in tetrahydrofuran (100 mL) under nitrogen protection and cooled to -30 °C. Subsequently, a solution of tetrahydrofuran (30 mL) containing 2-(4-bromophenyl)-1-morpholinoethanone (12.5 g, 44.17 mmol, 1.00 eq.) was slowly added dropwise to this suspension. The reaction mixture was stirred continuously at -30°C for 30 minutes, after which it was brought to room temperature and continued stirring for 2 hours. Upon completion of the reaction, 3.5 mL of water, 10 mL of 15% aqueous sodium hydroxide solution and 3.5 mL of water were added sequentially to quench the reaction. The insoluble solids were removed by filtration and the filtrate was extracted with ethyl acetate (1 x 150 mL). The organic layers were combined, washed successively with brine (2 × 30 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 11.5 g of 4-(4-bromophenylethyl)morpholine as a white solid in 97% yield.LC-MS analysis: (ES, m/z): 311 [M + CH3CN + H]+, 270 [M + H]+, 130, 102.
References
[1] Patent: WO2013/155338, 2013, A2. Location in patent: Page/Page column 171-172
[2] Patent: US2015/329503, 2015, A1. Location in patent: Paragraph 0704
[3] Chemical Communications, 2016, vol. 52, # 9, p. 1855 - 1858
4-(4-Bromophenethyl)morpholine Preparation Products And Raw materials
Raw materials
Preparation Products
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