2-Chloro-3-fluoro-5-nitropyridine
- Product Name
- 2-Chloro-3-fluoro-5-nitropyridine
- CAS No.
- 1079179-12-6
- Chemical Name
- 2-Chloro-3-fluoro-5-nitropyridine
- Synonyms
- 2-Chloro-3-fluoro-5-nitropyridine;Pyridine, 2-chloro-3-fluoro-5-nitro-;2-Chloro-3-fluoro-5-nitropyridine ISO 9001：2015 REACH
- CBNumber
- CB32490918
- Molecular Formula
- C5H2ClFN2O2
- Formula Weight
- 176.53
- MOL File
- 1079179-12-6.mol
2-Chloro-3-fluoro-5-nitropyridine Property
- Boiling point:
- 247.0±35.0 °C(Predicted)
- Density
- 1.595±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -4.41±0.10(Predicted)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C5H2ClFN2O2/c6-5-4(7)1-3(2-8-5)9(10)11/h1-2H
- InChIKey
- SHXURKRHCSAERA-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C([N+]([O-])=O)C=C1F
Safety
- HS Code
- 2933399990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C349160
- Product name
- 2-Chloro-3-fluoro-5-nitropyridine
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C349160
- Product name
- 2-Chloro-3-fluoro-5-nitropyridine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-W003883
- Product name
- 2-Chloro-3-fluoro-5-nitropyridine
- Purity
- 99.95%
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- PC910735
- Product name
- 2-Chloro-3-fluoro-5-nitropyridine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- X7340
- Product name
- 2-Chloro-3-fluoro-5-nitropyridine
- Packaging
- 1g
- Price
- $133
- Updated
- 2021/12/16
2-Chloro-3-fluoro-5-nitropyridine Chemical Properties,Usage,Production
Synthesis
1033202-14-0
1079179-12-6
General procedure for the synthesis of 2-chloro-3-fluoro-5-nitropyridine from 3-fluoro-5-nitropyridin-2(1H)-one: To a stirred solution of 3-fluoro-5-nitropyridin-2-ol (1.5 g, 9.48 mmol) in phosphorus trichloride (15 mL) was slowly added phosphorus pentachloride (2.96 g, 14.22 mmol) at 60 °C. The reaction mixture was kept continuously stirred at 60 °C for 10 hours. After the reaction was completed, the mixture was cooled to room temperature and carefully poured into crushed ice. Extraction was carried out with ethyl acetate (3 x 20 mL). The organic layers were combined and washed with saturated sodium carbonate solution (25 mL) and subsequently dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to give the crude product. Finally, the crude product was purified by silica gel column chromatography (100-200 mesh, eluent 5% ethyl acetate in hexane solution) to afford the target compound 2-chloro-3-fluoro-5-nitropyridine (1.62 g, 97% yield).
References
[1] Patent: WO2013/13817, 2013, A1. Location in patent: Page/Page column 96; 97
[2] Patent: WO2013/13815, 2013, A1. Location in patent: Page/Page column 131
[3] Patent: US2013/29961, 2013, A1. Location in patent: Paragraph 0656
[4] Patent: US2013/29962, 2013, A1. Location in patent: Paragraph 0761
[5] MedChemComm, 2016, vol. 7, # 5, p. 1022 - 1032
2-Chloro-3-fluoro-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-3-fluoro-5-nitropyridine manufacturers
- Product
- 2-Chloro-3-fluoro-5-nitropyridine 1079179-12-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-23
- Product
- 2-Chloro-3-fluoro-5-nitropyridine 1079179-12-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02